Regulation and function of interleukin-36 cytokines

被引：187

作者：

Bassoy, Esen Yonca ^{[1
,2
,3
]}

Towne, Jennifer E. ^{[4
]}

Gabay, Cem ^{[1
,2
,3
]}

机构：

[1] Univ Hosp Geneva, Dept Internal Med Specialties, Div Rheumatol, Geneva, Switzerland

[2] Univ Hosp Geneva, Dept Pathol Immunol, Geneva, Switzerland

[3] Univ Geneva, Geneva, Switzerland

[4] Janssen Res & Dev, Immunol Discovery, San Diego, CA 92121 USA

来源：

IMMUNOLOGICAL REVIEWS | 2018年 / 281卷 / 01期

基金：

瑞士国家科学基金会;

关键词：

IL-1; family; inflammation; intestine; lung; psoriasis; GENERALIZED PUSTULAR PSORIASIS; BRONCHIAL EPITHELIAL-CELLS; IL-36 RECEPTOR ANTAGONIST; SKIN INFLAMMATION; AP1S3; MUTATIONS; FAMILY-MEMBERS; T-LYMPHOCYTES; MYELOID CELLS; EXPRESSION; ACTIVATION;

D O I：

10.1111/imr.12610

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

071005 [微生物学]; 100108 [医学免疫学];

摘要：

The interleukin (IL)-36 cytokines include 3 agonists, IL-36, IL-36, and IL-36 that bind to a common receptor composed of IL-36R and IL-1RAcP to stimulate inflammatory responses. IL-36Ra is a natural antagonist that binds to IL-36R, but does not recruit the co-receptor IL-1RAcP and does not stimulate any intracellular responses. The IL-36 cytokines are expressed predominantly by epithelial cells and act on a number of cells including immune cells, epithelial cells, and fibroblasts. Processing of the N-terminus is required for full agonist or antagonist activity for all IL-36 members. The role of IL-36 has been extensively demonstrated in the skin where it can act on keratinocytes and immune cells to induce a robust inflammatory response that has been implicated in psoriatic disorders. Emerging data also suggest a role for this cytokine family in pulmonary and intestinal physiology and pathology.

引用

页码：169 / 178

页数：10

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