Delivery of fluorescent probes using iron oxide particles as carriers enables in-vivo labeling of migrating neural precursors for magnetic resonance imaging and optical imaging

被引：14

作者：

Sumner, James P. ^{[1
]}

Conroy, Richard ^{[1
,2
]}

Shapiro, Erik M. ^{[3
]}

Moreland, John ^{[2
]}

Koretsky, Alan P. ^{[1
]}

机构：

[1] Natl Inst Neurol Disorders & Stroke, Lab Funct & Mol Imaging, NIH, Bethesda, MD 20892 USA

[2] Natl Inst Stand & Technol, Boulder, CO USA

[3] Yale Univ, Sch Med, Dept Radiol, New Haven, CT 06510 USA

来源：

JOURNAL OF BIOMEDICAL OPTICS | 2007年 / 12卷 / 05期

关键词：

magnetic resonance imaging; fluorescent probes; iron oxide particles; optical imaging;

D O I：

10.1117/1.2800294

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

Iron oxide particles are becoming an important contrast agent for magnetic resonance imaging (MRI) cell tracking studies. Simultaneous delivery of fluorescence indicators with the particles to individual cells offers the possibility of correlating optical images and MRI. In this work, it is demonstrated that micron-sized iron oxide particles (MPIOs) can be used as a carrier to deliver fluorescent probes to cells in culture as well as to migrating neural progenitors in vivo. Migrating progenitors were tracked with MRI and easily identified by histology because of the fluorescent probe. These data suggest that using MPIOs to deliver fluorescent probes should make it possible to combine MRI and optical imaging for in vivo cell tracking. (c) 2007 Society of Photo-Optical Instrumentation Engineers.

引用

页数：6

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