Induction and adaptation of chaperone-assisted selective autophagy CASA in response to resistance exercise in human skeletal muscle

被引：148

作者：

Ulbricht, Anna ^{[1
]}

Gehlert, Sebastian ^{[2
]}

Leciejewski, Barbara ^{[1
]}

Schiffer, Thorsten ^{[3
]}

Bloch, Wilhelm ^{[2
]}

Hoehfeld, Joerg ^{[1
]}

机构：

[1] Univ Bonn, Inst Cell Biol, Bonn, Germany

[2] German Sport Univ Cologne, Dept Mol & Cellular Sport Med, Cologne, Germany

[3] German Sport Univ Cologne, Outpatient Clin Sports Traumatol, Cologne, Germany

来源：

AUTOPHAGY | 2015年 / 11卷 / 03期

关键词：

autophagy; BAG3; chaperone; exercise; HSPB8; human subjects; mechanical tension; muscle; proteostasis; stress; CASA; chaperone-assisted selective autophagy; CK; creatine kinase; TBS; tris-buffered saline; PROTEIN-QUALITY CONTROL; BAG3; CARDIOMYOPATHY; INHIBITION; MYOPATHY; DAMAGE; DEATH;

D O I：

10.1080/15548627.2015.1017186

中图分类号：

Q2 [细胞生物学];

学科分类号：

071013 [干细胞生物学];

摘要：

Chaperone-assisted selective autophagy (CASA) is a tension-induced degradation pathway essential for muscle maintenance. Impairment of CASA causes childhood muscle dystrophy and cardiomyopathy. However, the importance of CASA for muscle function in healthy individuals has remained elusive so far. Here we describe the impact of strength training on CASA in a group of healthy and moderately trained men. We show that strenuous resistance exercise causes an acute induction of CASA in affected muscles to degrade mechanically damaged cytoskeleton proteins. Moreover, repeated resistance exercise during 4 wk of training led to an increased expression of CASA components. In human skeletal muscle, CASA apparently acts as a central adaptation mechanism that responds to acute physical exercise and to repeated mechanical stimulation.

引用

页码：538 / 546

页数：9

共 32 条

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