Cisapride-induced torsades de pointes

被引：55

作者：

Vitola, J

Vukanovic, J

Roden, DM

机构：

[1] Vanderbilt Univ, Sch Med, Div Clin Pharmacol, Dept Med, Nashville, TN 37232 USA

[2] Vanderbilt Univ, Sch Med, Dept Pharmacol, Nashville, TN 37232 USA

来源：

JOURNAL OF CARDIOVASCULAR ELECTROPHYSIOLOGY | 1998年 / 9卷 / 10期

关键词：

cisapride; potassium channels; torsades de pointes;

D O I：

10.1111/j.1540-8167.1998.tb00888.x

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Two cases of torsades de pointes associated with cisapride are presented, both in association with concomitant drug therapy that inhibits cisapride biotransformation, In one case, plasma cisapride was elevated days after the event, strongly supporting a role for accumulation of the drug in causing the arrhythmia, It is emphasized that these adverse drug reactions are not idiosyncratic, but rather are predictable based on an understanding of the underlying mechanisms.

引用

收藏

页码：1109 / 1113

页数：5

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