Fo Shou San, an Ancient Herbal Decoction Prepared from Rhizoma Chuanxiong and Radix Angelicae Sinensis, Stimulates the Production of Hemoglobin and Erythropoietin in Cultured Cells

被引：24

作者：

Bi, Cathy Wen Chuan ^{[1
,2
]}

Xie, Heidi Qun Hui ^{[1
,2
]}

Xu, Li ^{[1
,2
]}

Li, Jun ^{[1
,2
]}

Cheung, Anna Wing Han ^{[1
,2
]}

Zhu, Judy Ting Ting ^{[1
,2
]}

Zheng, Yu Zhong ^{[1
,2
]}

Chen, Vicky Ping ^{[1
,2
]}

Lau, David Tai Wai ^{[1
,2
]}

Choi, Roy Chi Yan ^{[1
,2
]}

Wang, Tie Jie ^{[1
,2
,3
]}

Dong, Tina Ting Xia ^{[1
,2
]}

Tsim, Karl Wah Keung ^{[1
,2
]}

机构：

[1] Hong Kong Univ Sci & Technol, Dept Biol, Hong Kong, Hong Kong, Peoples R China

[2] Hong Kong Univ Sci & Technol, Ctr Chinese Med, Hong Kong, Hong Kong, Peoples R China

[3] Shenzhen Municipal Inst Drug Control, Shenzhen, Peoples R China

来源：

PLANTA MEDICA | 2010年 / 76卷 / 14期

关键词：

Angelica sinensis; Ligusticum chuanxiong; Umbelliferae; ERYTHROID-DIFFERENTIATION; CHINESE; IDENTIFICATION; LEUKEMIA; DRUG;

D O I：

10.1055/s-0029-1241003

中图分类号：

Q94 [植物学];

学科分类号：

071001 [植物学];

摘要：

tured K562 human leukemia cells and Hep3B human hepatocellular carcinoma cells. Application of FSS in cultured K562 cells inhibited cell proliferation and subsequently induced the production of hemoglobin. Additionally, the mRNA expression of erythropoietin (EPO) was induced in a dose-dependent manner when FSS was applied to Hep3B cells. The current results reveal the effects of FSS in different cell models, paving a direction for mechanistic studies.Fo Shou San (FSS) is an ancient herbal decoction comprised of Rhizoma Chuanxiong (RC; Chuanxiong) and Radix Angelicae Sinensis (RAS; Danggui) in a ratio of 2:3. It is mainly prescribed for patients having a blood deficiency. This combination is considered the most popular herb pair among Chinese medicines; however, the rationale of having these two chemically similar herbs within the decoction has historically not been made clear. Here, we attempted to reveal the chemical and biological properties of this decoction as a means to deduce its mechanism of action. The effects of FSS were determined in different cell culture models. With respect to stimulation of blood circulation, FSS inhibited ADP-mediated platelet aggregation in a dose-dependent manner. In order to reveal the hematopoietic effect of this decoction, FSS was applied onto cul

引用

页码：1525 / 1529

页数：5

共 22 条

[1]

AVALOS BR, 1988, BLOOD, V71, P1720

[2]

Chen Z, 1997, J Tongji Med Univ, V17, P218

[3]

Regulation of erythropoietin gene expression depends on two different oxygen-sensing mechanisms [J].