Human coding and noncoding DNA: Compositional correlations

被引:91
作者
Clay, O
Caccio, S
Zoubak, S
Mouchiroud, D
Bernardi, G
机构
[1] INST JACQUES MONOD,GENET MOLEC LAB,F-75005 PARIS,FRANCE
[2] UNIV LYON 1,LAB BIOMETRIE GENET & BIOL POPULAT,URA 243,F-69600 VILLEURBANNE,FRANCE
[3] UKRAINIAN ACAD SCI,INST MOLEC BIOL & GENET,KIEV 252627,UKRAINE
关键词
D O I
10.1006/mpev.1996.0002
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
As the correlations between GC levels in third codon positions (GC(3)) and intergenic sequence GC levels can be used to assess the distribution of genes in the human genome, they were studied in detail. Previous work from our laboratory has demonstrated the existence of linear correlations between GC levels of exons, introns, third codon positions, 5' flanking regions of genes, and long genomic DNA sequences (greater than or equal to 10 kb) or DNA molecules (50-100 kb) in which the genes are embedded. The present study confirms and extends the previous results using a larger set of data, Furthermore, an analysis of 4270 human genomic DNA and cDNA sequences has allowed us to confirm a correlation of GC(3) against GC(1+2). Recent additions to the sequence database have also allowed separate analyses of the 5' flanking regions of CpG island and non-CpG island genes as well as analyses of 3' flanking regions, which suggest that the GC levels of 3' flanking regions are closer to those of intergenic DNA than are those of Other regions of genes. (C) 1996 Academic Press, Inc.
引用
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页码:2 / 12
页数:11
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