Myostatin and its Regulation: A Comprehensive Review of Myostatin Inhibiting Strategies

被引：75

作者：

Baig, Mohammad Hassan ^{[1
]}

Ahmad, Khurshid ^{[2
,3
]}

Moon, Jun Sung ^{[4
]}

Park, So-Young ^{[5
]}

Ho Lim, Jeong ^{[2
,3
]}

Chun, Hee Jin ^{[2
,3
]}

Qadri, Afsha Fatima ^{[2
]}

Hwang, Ye Chan ^{[2
]}

Jan, Arif Tasleem ^{[6
]}

Ahmad, Syed Sayeed ^{[2
]}

Ali, Shahid ^{[2
]}

Shaikh, Sibhghatulla ^{[2
]}

Lee, Eun Ju ^{[2
,3
]}

Choi, Inho ^{[2
,3
]}

机构：

[1] Yonsei Univ Coll Med, Gangnam Severance Hosp, Dept Family Med, Seoul, South Korea

[2] Yeungnam Univ, Dept Med Biotechnol, Gyongsan, South Korea

[3] Yeungnam Univ, Res Inst Cell Culture, Gyongsan, South Korea

[4] Yeungnam Univ, Coll Med, Dept Internal Med, Daegu, South Korea

[5] Yeungnam Univ, Coll Med, Dept Physiol, Daegu, South Korea

[6] Baba Ghulam Shah Badshah Univ, Sch Biosci & Biotechnol, Rajouri, India

来源：

FRONTIERS IN PHYSIOLOGY | 2022年 / 13卷

基金：

新加坡国家研究基金会;

关键词：

myostatin; skeletal muscle; MSTN inhibitors; natural compounds; peptides; SKELETAL-MUSCLE GROWTH; SATELLITE CELLS; IN-VITRO; MYOBLAST DIFFERENTIATION; ACTRIIB ANTAGONISM; CANCER CACHEXIA; PPAR-DELTA; EXPRESSION; PROTEIN; GHRELIN;

D O I：

10.3389/fphys.2022.876078

中图分类号：

Q4 [生理学];

学科分类号：

071003 [生理学];

摘要：

Myostatin (MSTN) is a well-reported negative regulator of muscle growth and a member of the transforming growth factor (TGF) family. MSTN has important functions in skeletal muscle (SM), and its crucial involvement in several disorders has made it an important therapeutic target. Several strategies based on the use of natural compounds to inhibitory peptides are being used to inhibit the activity of MSTN. This review delivers an overview of the current state of knowledge about SM and myogenesis with particular emphasis on the structural characteristics and regulatory functions of MSTN during myogenesis and its involvements in various muscle related disorders. In addition, we review the diverse approaches used to inhibit the activity of MSTN, especially in silico approaches to the screening of natural compounds and the design of novel short peptides derived from proteins that typically interact with MSTN.

引用

页数：16

共 184 条

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