Effects of Plant Extracts on HIV-1 Protease

被引：24

作者：

Ribeiro Filho, Jaime ^{[1
]}

Falcao, Heloina de Sousa ^{[1
]}

Batista, Leonia Maria ^{[1
]}

Barbosa Filho, Jose Maria ^{[1
]}

Piuvezam, Marcia Regina ^{[1
]}

机构：

[1] Univ Fed Paraiba UFPB, LTF, DCF, BR-58051970 Joao Pessoa, Paraiba, Brazil

来源：

CURRENT HIV RESEARCH | 2010年 / 8卷 / 07期

关键词：

Review; natural products; plants; AIDS; HIV-1; Protease; Anti-HIV drugs; INHIBITORY-ACTIVITY; MEDICINAL-PLANTS; IN-VITRO; ANTI-HIV-1; CONSTITUENTS; DERIVATIVES; TANNINS; ACID;

D O I：

10.2174/157016210793499204

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Acquired immunodeficiency syndrome (AIDS) is one of the most important public health problems, affecting many people every day. This syndrome is caused by the human immunodeficiency virus (HIV) and the HIV-1 protease plays an essential role by promoting virus maturation and thus infecting new cells. The HIV-1 protease is one of the main targets for anti-HIV drug therapy. The present work is a literature survey of plant extracts whose activity has been studied on HIV-1 protease. Here we list 275 species of medicinal plants, distributed in 99 families, with their place of origin, part used, type of extract, concentration and activity. We aim with this work to provide data that could be used in the research and development of new therapeutic agents for AIDS treatment.

引用

页码：531 / 544

页数：14

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