Chemical synthesis of UDP-β-L-arabinofuranose and its turnover to UDP-β-L-arabinopyranose by UDP-galactopyranose mutase

被引：33

作者：

Zhang, QB

Liu, HW

机构：

[1] Univ Minnesota, Dept Chem, Minneapolis, MN 55455 USA

[2] Univ Texas, Coll Pharm, Div Med Chem, Austin, TX 78712 USA

[3] Univ Texas, Dept Chem & Biochem, Austin, TX 78712 USA

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2001年 / 11卷 / 02期

关键词：

D O I：

10.1016/S0960-894X(00)00616-8

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Uridine-5'-diphospho-beta -L-arabinofuranose, a possible donor of L-arabinofuranose residues in plants, was synthesized. This compound, in the presence of UDP-galactopyranose mutase, underwent interconversion with UDP-beta -L-arabinopyranose that is a likely precursor of L-arabinofuranose in vivo. This result provided a working model for the biogenesis of arabinofuranose in plants. (C) 2001 Elsevier Science Ltd. All rights reserved.

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页码：145 / 149

页数：5

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