GENOMIC MEDICINE Genomics, Type 2 Diabetes, and Obesity

被引:646
作者
McCarthy, Mark I. [1 ,2 ,3 ]
机构
[1] Univ Oxford, Oxford Ctr Diabet Endocrinol & Metab, Oxford OX3 7LJ, England
[2] Univ Oxford, Oxford Natl Inst Hlth Res, Biomed Res Ctr, Oxford OX3 7LJ, England
[3] Univ Oxford, Wellcome Trust Ctr Human Genet, Oxford OX3 7LJ, England
关键词
COMMON GENETIC-VARIANTS; LARGE-SCALE ASSOCIATION; C-REACTIVE PROTEIN; WIDE ASSOCIATION; FASTING GLUCOSE; FTO GENE; RISK LOCI; SUSCEPTIBILITY LOCI; ORAL SULFONYLUREAS; INSULIN-RESISTANCE;
D O I
10.1056/NEJMra0906948
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
[No abstract available]
引用
收藏
页码:2339 / 2350
页数:12
相关论文
共 82 条
[1]   The common PPARγ Pro12Ala polymorphism is associated with decreased risk of type 2 diabetes [J].
Altshuler, D ;
Hirschhorn, JN ;
Klannemark, M ;
Lindgren, CM ;
Vohl, MC ;
Nemesh, J ;
Lane, CR ;
Schaffner, SF ;
Bolk, S ;
Brewer, C ;
Tuomi, T ;
Gaudet, D ;
Hudson, TJ ;
Daly, M ;
Groop, L ;
Lander, ES .
NATURE GENETICS, 2000, 26 (01) :76-80
[2]   Common nonsynonymous variants in PCSK1 confer risk of obesity [J].
Benzinou, Michael ;
Creemers, John W. M. ;
Choquet, Helene ;
Lobbens, Stephane ;
Dina, Christian ;
Durand, Emmanuelle ;
Guerardel, Audrey ;
Boutin, Philippe ;
Jouret, Beatrice ;
Heude, Barbara ;
Balkau, Beverley ;
Tichet, Jean ;
Marre, Michel ;
Potoczna, Natascha ;
Horber, Fritz ;
Le Stunff, Catherine ;
Czernichow, Sebastien ;
Sandbaek, Annelli ;
Lauritzen, Torsten ;
Borch-Johnsen, Knut ;
Andersen, Gitte ;
Kiess, Wieland ;
Koerner, Antje ;
Kovacs, Peter ;
Jacobson, Peter ;
Carlsson, Lena M. S. ;
Walley, Andrew J. ;
Jorgensen, Torben ;
Hansen, Torben ;
Pedersen, Oluf ;
Meyre, David ;
Froguel, Philippe .
NATURE GENETICS, 2008, 40 (08) :943-945
[3]   Loss-of-Function Mutation in the Dioxygenase-Encoding FTO Gene Causes Severe Growth Retardation and Multiple Malformations [J].
Boissel, Sarah ;
Reish, Orit ;
Proulx, Karine ;
Kawagoe-Takaki, Hiroko ;
Sedgwick, Barbara ;
Yeo, Giles S. H. ;
Meyre, David ;
Golzio, Christelle ;
Molinari, Florence ;
Kadhom, Noman ;
Etchevers, Heather C. ;
Saudek, Vladimir ;
Farooqi, I. Sadaf ;
Froguel, Philippe ;
Lindahl, Tomas ;
O'Rahilly, Stephen ;
Munnich, Arnold ;
Colleaux, Laurence .
AMERICAN JOURNAL OF HUMAN GENETICS, 2009, 85 (01) :106-111
[4]   A variant near MTNR1B is associated with increased fasting plasma glucose levels and type 2 diabetes risk [J].
Bouatia-Naji, Nabila ;
Bonnefond, Amelie ;
Cavalcanti-Proenca, Christine ;
Sparso, Thomas ;
Holmkvist, Johan ;
Marchand, Marion ;
Delplanque, Jerome ;
Lobbens, Stephane ;
Rocheleau, Ghislain ;
Durand, Emmanuelle ;
De Graeve, Franck ;
Chevre, Jean-Claude ;
Borch-Johnsen, Knut ;
Hartikainen, Anna-Liisa ;
Ruokonen, Aimo ;
Tichet, Jean ;
Marre, Michel ;
Weill, Jacques ;
Heude, Barbara ;
Tauber, Maithe ;
Lemaire, Katleen ;
Schuit, Frans ;
Elliott, Paul ;
Jorgensen, Torben ;
Charpentier, Guillaume ;
Hadjadj, Samy ;
Cauchi, Stephane ;
Vaxillaire, Martine ;
Sladek, Robert ;
Visvikis-Siest, Sophie ;
Balkau, Beverley ;
Levy-Marchal, Claire ;
Pattou, Francois ;
Meyre, David ;
Blakemore, Alexandra I. F. ;
Jarvelin, Marjo-Riita ;
Walley, Andrew J. ;
Hansen, Torben ;
Dina, Christian ;
Pedersen, Oluf ;
Froguel, Philippe .
NATURE GENETICS, 2009, 41 (01) :89-94
[5]   Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls [J].
Burton, Paul R. ;
Clayton, David G. ;
Cardon, Lon R. ;
Craddock, Nick ;
Deloukas, Panos ;
Duncanson, Audrey ;
Kwiatkowski, Dominic P. ;
McCarthy, Mark I. ;
Ouwehand, Willem H. ;
Samani, Nilesh J. ;
Todd, John A. ;
Donnelly, Peter ;
Barrett, Jeffrey C. ;
Davison, Dan ;
Easton, Doug ;
Evans, David ;
Leung, Hin-Tak ;
Marchini, Jonathan L. ;
Morris, Andrew P. ;
Spencer, Chris C. A. ;
Tobin, Martin D. ;
Attwood, Antony P. ;
Boorman, James P. ;
Cant, Barbara ;
Everson, Ursula ;
Hussey, Judith M. ;
Jolley, Jennifer D. ;
Knight, Alexandra S. ;
Koch, Kerstin ;
Meech, Elizabeth ;
Nutland, Sarah ;
Prowse, Christopher V. ;
Stevens, Helen E. ;
Taylor, Niall C. ;
Walters, Graham R. ;
Walker, Neil M. ;
Watkins, Nicholas A. ;
Winzer, Thilo ;
Jones, Richard W. ;
McArdle, Wendy L. ;
Ring, Susan M. ;
Strachan, David P. ;
Pembrey, Marcus ;
Breen, Gerome ;
St Clair, David ;
Caesar, Sian ;
Gordon-Smith, Katherine ;
Jones, Lisa ;
Fraser, Christine ;
Green, Elain K. .
NATURE, 2007, 447 (7145) :661-678
[6]   Common genetic variation near MC4R is associated with waist circumference and insulin resistance [J].
Chambers, John C. ;
Elliott, Paul ;
Zabaneh, Delilah ;
Zhang, Weihua ;
Li, Yun ;
Froguel, Philippe ;
Balding, David ;
Scott, James ;
Kooner, Jaspal S. .
NATURE GENETICS, 2008, 40 (06) :716-718
[7]   A Mouse Model for the Metabolic Effects of the Human Fat Mass and Obesity Associated FTO Gene [J].
Church, Chris ;
Lee, Sheena ;
Bagg, Eleanor A. L. ;
McTaggart, James S. ;
Deacon, Robert ;
Gerken, Thomas ;
Lee, Angela ;
Moir, Lee ;
Mecinovic, Jasmin ;
Quwailid, Mohamed M. ;
Schofield, Christopher J. ;
Ashcroft, Frances M. ;
Cox, Roger D. .
PLOS GENETICS, 2009, 5 (08)
[8]   Medicine - Life cycle of translational research for medical interventions [J].
Contopoulos-Ioannidis, Despina G. ;
Alexiou, George A. ;
Gouvias, Theodore C. ;
Ioannidis, John P. A. .
SCIENCE, 2008, 321 (5894) :1298-1299
[9]   Joint Effects of Common Genetic Variants on the Risk for Type 2 Diabetes in U. S. Men and Women of European Ancestry [J].
Cornelis, Marilyn C. ;
Qi, Lu ;
Zhang, Cuilin ;
Kraft, Peter ;
Manson, JoAnn ;
Cai, Tianxi ;
Hunter, David J. ;
Hu, Frank B. .
ANNALS OF INTERNAL MEDICINE, 2009, 150 (08) :541-W98
[10]   Variation in FTO contributes to childhood obesity and severe adult obesity [J].
Dina, Christian ;
Meyre, David ;
Gallina, Sophie ;
Durand, Emmanuelle ;
Koerner, Antje ;
Jacobson, Peter ;
Carlsson, Lena M. S. ;
Kiess, Wieland ;
Vatin, Vincent ;
Lecoeur, Cecile ;
Delplanque, Jerome ;
Vaillant, Emmanuel ;
Pattou, Francois ;
Ruiz, Juan ;
Weill, Jacques ;
Levy-Marchal, Claire ;
Horber, Fritz ;
Potoczna, Natascha ;
Hercberg, Serge ;
Le Stunff, Catherine ;
Bougneres, Pierre ;
Kovacs, Peter ;
Marre, Michel ;
Balkau, Beverley ;
Cauchi, Stephane ;
Chevre, Jean-Claude ;
Froguel, Philippe .
NATURE GENETICS, 2007, 39 (06) :724-726