Antimycobacterial activity of mixed-ligand copper quinolone complexes

New mixed-ligand Cu-II, complexes: [Cu(cf)(phen)Cl)](BF4) . 4H(2)O (3), [Cu(cf)(bipy)(Cl)](BF4) . 2H(2)O (4) and [Cu(cf)(dafone)(Cl)](BF4) . 2H(2)O (5) ( cf = ciprofloxacin, phen = 1,10-phenanthroline, bipy = 2,2'-bipyridine and dafone = 4,5-diazafluoren-9-one) have been isolated and characterized by elemental analyses, i. r.,u.v.-vis. spectra, magnetic susceptibility and cyclic voltammetry. Complex (4) crystallizes in the monoclinic space group P2(1)/n with a = 13.8919(13) Angstrom, b = 14.5718(13) Angstrom, c = 14.0725(13) Angstrom, beta = 95.150(2) degrees, V = 2837.2(5) Angstrom(3). All complexes possess square-pyramidal geometry. The antimycobacterial activity of ciprofloxacin and complexes (3-5) has been evaluated against Mycobacterium smegmatis, which shows clear enhancement in the antitubercular activity upon copper complexation with N-N donors.