Labelling of Re-ABP with 188Re for bone pain palliation

被引：14

作者：

de Murphy, CA

Ferro-Flores, G

Pedraza-López, M

Meléndez-Alafort, L

Croft, BY

Ramírez, FD

Padilla, J

机构：

[1] Inst Nacl Nutr Salvador Zubiran, Dept Nucl Med, Mexico City 14000, DF, Mexico

[2] Inst Nacl Invest Nucl, Dept Mat Radiact, Salazar 52045, Mexico, Mexico

[3] Inst Nacl Invest Nucl, Dept Quim, Salazar 52045, Mexico, Mexico

[4] NCI, NIH, Bethesda, MD 20892 USA

[5] Univ Autonoma Metropolitana Iztapalapa, Dept Quim, Mexico City 09820, DF, Mexico

来源：

APPLIED RADIATION AND ISOTOPES | 2001年 / 54卷 / 03期

关键词：

Re-188-ABP; Re-188-alendronate; Re-188 labelled bisphosphonates;

D O I：

10.1016/S0969-8043(00)00296-7

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

Etidronate and medronate have been labelled with technetium-99m (Tc-99m-HEDP, Tc-99m-MDP) for bone scanning and, with rhenium-188 (Re-188-HEDP) to palliate the pain resulting from bone metastases. The objective of this study was to label alendronate, ABP, a new bisphosphonate, with SnF2-reduced-Re-188. The reagents for the 5 mg ABP kit were SnF2, KReO4 and gentisic acid at acid pH. The chemical, spectroscopic and microscopic characteristics, quality control, rat bone uptake of [Re-188]Re-ABP and similarities with Tc-99m-ABP are presented. We conclude that this is a promising new radiopharmaceutical for bone metastases pain palliation. (C) 2001 Elsevier Science Ltd. All rights reserved.

引用

页码：435 / 442

页数：8

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