Kisspeptins and GPR54 - The new biology of the mammalian GnRH axis

被引：30

作者：

Aparicio, SAJR

机构：

[1] Univ Cambridge, Dept Oncol, Hutchison MRC Res Ctr, Cambridge CB2 2XZ, England

[2] Paradigm Therapeut Ltd, Cambridge CB4 0WA, England

来源：

CELL METABOLISM | 2005年 / 1卷 / 05期

关键词：

D O I：

10.1016/j.cmet.2005.04.001

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Recent genetic evidence in humans and from mouse knockouts has linked kisspeptin-driven GPR54 signaling to the regulation of GnRH release from the hypothalamus. These molecules appear to represent a previously unsuspected control point for GnRH secretion, with important implications for the biology and pathology of the sex steroid axis.

引用

收藏

页码：293 / 296

页数：4

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