Rapamycin (sirolimus) inhibits heart cell growth in vitro

被引：8

作者：

Burton, PBJ ^{[1
]}

Yacoub, MH ^{[1
]}

Barton, PJR ^{[1
]}

机构：

[1] Univ London Imperial Coll Sci Technol & Med, Sch Med, Natl Heart & Lung Inst, London SW3 6LY, England

来源：

PEDIATRIC CARDIOLOGY | 1998年 / 19卷 / 06期

关键词：

infant; neonate; transplant; heart; rapamycin; sirolimus;

D O I：

10.1007/s002469900359

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The success of infant and neonatal heart transplantation has increased dramatically since the mid-1980s, This success is due both to improved medical and surgical techniques and better pharmacological management of rejection episodes. We report here the results of in vitro studies designed to investigate the effect of rapamycin (a macrolide antibiotic with potent antirejection activity) on the proliferation of fetal cardiac myocytes. Our data suggest that rapamycin inhibits the proliferation of these cells, which is an effect that appears to be irreversible. This inhibition is relevant to the use of rapamycin in the treatment of rejection episodes in the infant and neonate, in which cardiac myocyte development is incomplete.

引用

页码：468 / 470

页数：3

共 9 条

[1] Rapamycin inhibits alpha(1)-adrenergic receptor-stimulated cardiac myocyte hypertrophy but not activation of hypertrophy-associated genes - Evidence for involvement of p70 S6 kinase [J].