Polycystic ovary syndrome: an ancient disorder?

被引：140

作者：

Azziz, Ricardo ^{[1
,4
,5
]}

Dumesic, Daniel A. ^{[4
,6
]}

Goodarzi, Mark O. ^{[1
,2
,3
,5
]}

机构：

[1] Cedars Sinai Med Ctr, Dept Obstet & Gynecol, Los Angeles, CA 90048 USA

[2] Cedars Sinai Med Ctr, Div Endocrinol Diabet & Metab, Dept Med, Los Angeles, CA 90048 USA

[3] Cedars Sinai Med Ctr, Inst Med Genet, Los Angeles, CA 90048 USA

[4] Univ Calif Los Angeles, Sch Med, Dept Obstet & Gynecol, Los Angeles, CA 90024 USA

[5] Univ Calif Los Angeles, Sch Med, Dept Med, Los Angeles, CA 90024 USA

[6] Univ Wisconsin, Natl Primate Res Ctr, Madison, WI USA

来源：

FERTILITY AND STERILITY | 2011年 / 95卷 / 05期

关键词：

PCOS; evolution; susceptibility genes; INSULIN-RESISTANCE; MINERAL DENSITY; YOUNG-WOMEN; PREVALENCE; DISEASE; SUSCEPTIBILITY; FEATURES;

D O I：

10.1016/j.fertnstert.2010.09.032

中图分类号：

R71 [妇产科学];

学科分类号：

100211 [妇产科学];

摘要：

Polycystic ovary syndrome (PCOS) appears to be an ancient disorder, which has persisted in human evolution despite reduced fecundity because of the benefits to affected women such as greater sturdiness and improved energy utilization, a rearing advantage for their children and kin, and a reduction in the risk of perinatal mortality. This raises the possibility that gene variants that are eventually found to be associated with PCOS will be similar across ethnic groups and races. (Fertil Steril (R) 2011;95:1544-8. (C) 2011 by American Society for Reproductive Medicine.)

引用

收藏

页码：1544 / 1548

页数：5

相关论文

共 37 条

[1]

Computed Tomographic Assessment of Atherosclerosis in Ancient Egyptian Mummies [J].

Allam, Adel H. ;

Thompson, Randall C. ;

Wann, L. Samuel ;

Miyamoto, Michael I. ;

Thomas, Gregory S. .

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 2009, 302 (19) :2091-2094

[2]

A prospective study of the prevalence of the polycystic ovary syndrome in unselected Caucasian women from Spain [J].

Asunción, M ;

Calvo, RM ;

San Millán, JL ;

Sancho, J ;

Avila, S ;

Escobar-Morreale, HF .

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 2000, 85 (07) :2434-2438

[3]

The prevalence and features of the polycystic ovary syndrome in an unselected population [J].

Azziz, R ;

Woods, KS ;

Reyna, R ;

Key, TJ ;

Knochenhauer, ES ;

Yildiz, BO .

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 2004, 89 (06) :2745-2749

[4]

Troglitazone improves ovulation and hirsutism in the polycystic ovary syndrome: A multicenter, double blind, placebo-controlled trial [J].

Azziz, R ;

Ehrmann, D ;

Legro, RS ;

Whitcomb, RW ;

Hanley, R ;

Fereshetian, AG ;

O'Keefe, M ;

Ghazzi, MN .

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 2001, 86 (04) :1626-1632

[5]

Fetal programming of coronary heart disease [J].

Barker, DJP .

TRENDS IN ENDOCRINOLOGY AND METABOLISM, 2002, 13 (09) :364-368

[6]

Natural selection on genes that underlie human disease susceptibility [J].

Blekhman, Ran ;

Man, Orna ;

Herrmann, Leslie ;

Boyko, Adam R. ;

Indap, Amit ;

Kosiol, Carolin ;

Bustamante, Carlos D. ;

Teshima, Kosuke M. ;

Przeworskil, Molly .

CURRENT BIOLOGY, 2008, 18 (12) :883-889

[7]

Correlates of increased lean muscle mass in women with polycystic ovary syndrome [J].

Carmina, E. ;

Guastella, E. ;

Longo, R. A. ;

Rini, G. B. ;

Lobo, R. A. .

EUROPEAN JOURNAL OF ENDOCRINOLOGY, 2009, 161 (04) :583-589

[8]

Eating, exercise, and "thrifty" genotypes: connecting the dots toward an evolutionary understanding of modern chronic diseases [J].

Chakravarthy, MV ;

Booth, FW .

JOURNAL OF APPLIED PHYSIOLOGY, 2004, 96 (01) :3-10

[9]

'Diabetes' as described by Byzantine writers from the fourth to the ninth century AD: the Graeco-Roman influence [J].

Christopoulou-Aletra, H. ;

Papavramidou, N. .

DIABETOLOGIA, 2008, 51 (05) :892-896

[10]

Cochran G., 2009, 10 000 YEAR EXPLOSIO

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