Endothelial biology in the post-menopausal obese woman

被引：20

作者：

Meadows, Judith L. ^{[1
]}

Vaughan, Douglas E. ^{[1
]}

机构：

[1] NW Univ Feinberg, Sch Med, Dept Med, Div Cardiol, Chicago, IL 60611 USA

来源：

MATURITAS | 2011年 / 69卷 / 02期

基金：

美国国家卫生研究院;

关键词：

Endothelial function; Nitric oxide; Vasodilation; Menopause; Gender; Vascular function; Cardiovascular disease; Obesity; Aging; Metabolic syndrome; PLASMINOGEN ACTIVATOR RELEASE; OBSTRUCTIVE SLEEP-APNEA; ESTROGEN PLUS PROGESTIN; METABOLIC SYNDROME; INSULIN-RESISTANCE; DEPENDENT VASODILATION; OXIDATIVE STRESS; HORMONE-THERAPY; CARDIOVASCULAR-DISEASE; VASCULAR-DISEASE;

D O I：

10.1016/j.maturitas.2011.03.012

中图分类号：

R592 [老年病学]; C [社会科学总论];

学科分类号：

030301 [社会学]; 100201 [内科学];

摘要：

Women generally have a reduced risk of cardiovascular disease (CVD). However, this protection of gender diminishes rapidly after menopause and with advancing age, particularly in obese women. Alterations in vascular function are thought to a key early step in the development of atherosclerosis. In this review, we will describe the features of endothelial dysfunction in the post-menopausal obese female and discuss the interplay of aging, estrogen withdrawal, and obesity. The objectives include (1) a review of endothelial biology and endothelial dysfunction, and (2) a discussion how the endothelial function is altered in the context of aging, hormonal changes and insulin resistance. The clinical consequences of endothelial dysfunction and CVD will also be reviewed. (C) 2011 Elsevier Ireland Ltd. All rights reserved.

引用

页码：120 / 125

页数：6

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