Inactivating mutations of the chromatin remodeling gene ARID2 in hepatocellular carcinoma

被引：327

作者：

Li, Meng ^{[1
]}

Zhao, Hong ^{[2
,3
]}

Zhang, Xiaosong ^{[4
]}

Wood, Laura D. ^{[5
]}

Anders, Robert A. ^{[5
]}

Choti, Michael A. ^{[6
]}

Pawlik, Timothy M. ^{[6
]}

Daniel, Hubert D. ^{[5
]}

Kannangai, Rajesh ^{[5
]}

Offerhaus, G. Johan A. ^{[7
]}

Velculescu, Victor E. ^{[1
]}

Wang, Linfang ^{[3
,8
]}

Zhou, Shibin ^{[1
]}

Vogelstein, Bert ^{[1
]}

Hruban, Ralph H. ^{[5
]}

Papadopoulos, Nick ^{[1
]}

Cai, Jianqiang ^{[2
,3
]}

Torbenson, Michael S. ^{[5
]}

Kinzler, Kenneth W. ^{[1
]}

机构：

[1] Johns Hopkins Univ, Sch Med, Ludwig Ctr Canc Genet & Therapeut, Baltimore, MD 21218 USA

[2] Chinese Acad Med Sci, Dept Abdominal Surg Oncol, Canc Hosp, Beijing 100730, Peoples R China

[3] Peking Union Med Coll, Beijing 100021, Peoples R China

[4] Massachusetts Gen Hosp, Dept Med, Boston, MA 02114 USA

[5] Johns Hopkins Univ, Sch Med, Dept Pathol, Baltimore, MD 21205 USA

[6] Johns Hopkins Univ, Sch Med, Dept Surg, Baltimore, MD 21205 USA

[7] Univ Med Ctr Utrecht, Dept Pathol, Utrecht, Netherlands

[8] Chinese Acad Med Sci, Natl Lab Med Mol Biol, Inst Basic Med Sci, Beijing 100730, Peoples R China

来源：

NATURE GENETICS | 2011年 / 43卷 / 09期

基金：

美国国家卫生研究院;

关键词：

HEPATITIS-B-VIRUS; EXPRESSION; HEPATOCARCINOGENESIS; AFLATOXIN;

D O I：

10.1038/ng.903

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Through exomic sequencing of ten hepatitis C virus (HCV)-associated hepatocellular carcinomas (HCC) and subsequent evaluation of additional affected individuals, we discovered novel inactivating mutations of ARID2 in four major subtypes of HCC (HCV-associated HCC, hepatitis B virus (HBV)-associated HCC, alcohol-associated HCC and HCC with no known etiology). Notably, 18.2% of individuals with HCV-associated HCC in the United States and Europe harbored ARID2 inactivation mutations, suggesting that ARID2 is a tumor suppressor gene that is relatively commonly mutated in this tumor subtype.

引用

页码：828 / 829

页数：2

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