3-methoxycarbonyl-5-nitrophenyl boronic acid: high affinity diol recognition at neutral pH

被引：69

作者：

Mulla, HR ^{[1
]}

Agard, NJ ^{[1
]}

Basu, A ^{[1
]}

机构：

[1] Brown Univ, Dept Chem, Providence, RI 02912 USA

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2004年 / 14卷 / 01期

基金：

美国国家科学基金会;

关键词：

D O I：

10.1016/j.bmcl.2003.10.017

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Several boronic acids were screened for their ability to bind to diols. 3-Methoxycarbonyl-5-nitrophenyl boronic acid bound to both a catechol dye as well as fructose with a comparable affinity to that of an ortho-methylamino substituted boronic acid. This work suggests a greater role for appropriately functionalized electron deficient boronic acids in diol and carbohydrate recognition. (C) 2003 Elsevier Ltd. All rights reserved.

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页码：25 / 27

页数：3

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