Myofibroblast - like cells and liver fibrogenesis: Emerging concepts in a rapidly moving scenario

被引：138

作者：

Parola, Maurizio ^{[1
]}

Marra, Fabio ^{[2
]}

Pinzani, Massimo ^{[2
]}

机构：

[1] Univ Turin, Dipartimento Med & Oncol Sperimentale, I-10125 Turin, Italy

[2] Univ Florence, Dipartimento Med Interna, Ctr Ric Trasferimento & Alto Formaz, DENOTHE, I-54100 Florence, Italy

来源：

MOLECULAR ASPECTS OF MEDICINE | 2008年 / 29卷 / 1-2期

关键词：

liver fibrogenesis; hepatic myofibroblasts; pro-fibrogenic mechanisms in liver fibrosis; patterns of liver fibrosis; fibrosis progression in chronic liver diseases; hepatic stellate cells; portal myofibroblasts; bone marrow - derived mesenchymal stem cells;

D O I：

10.1016/j.mam.2007.09.002

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Fibrotic progression of chronic liver diseases of different aetiology to the common advanced-stage of cirrhosis can be envisaged as a dynamic and highly integrated cellular response to chronic liver injury. Liver fibrosis is accompanied by perpetuation of liver injury, chronic hepatitis and persisting activation of tissue repair mechanisms, leading eventually to excess deposition of ECM components. Liver fibrogenesis (i.e., the process) is sustained by populations of highly proliferative, profibrogenic and contractile MFs that, according to current literature, originate by a process of activation involving perisinusoidal HSC, portal fibroblasts and even bone marrow-derived MSC. In this short review emerging concepts in hepatic fibrogenesis and related molecular mechanisms, as provided by recent experimental and clinical studies, are presented. (C) 2007 Elsevier Ltd. All rights reserved.

引用

页码：58 / 66

页数：9

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