PEG-g-chitosan nanoparticles functionalized with the monoclonal antibody OX26 for brain drug targeting

被引：83

作者：

Monsalve, Yuliana ^{[1
]}

Tosi, Giovanni ^{[2
]}

Ruozi, Barbara ^{[2
]}

Belletti, Daniela ^{[2
]}

Vilella, Antonietta ^{[3
]}

Zoli, Michele ^{[3
]}

Vandelli, Maria Angela ^{[2
]}

Forni, Flavio ^{[2
]}

Lopez, Betty L. ^{[1
]}

Sierra, Ligia ^{[1
]}

机构：

[1] Univ Antioquia, Grp Invest Ciencia Mat, Inst Quim, Fac Ciencias Exactas & Nat, Medellin, Colombia

[2] Univ Modena & Reggio Emilia, Dept Life Sci, Pharmaceut Technol, Te Far TI Grp, I-41124 Modena, Italy

[3] Univ Modena & Reggio Emilia, Dept Biomed Metab & Neural Sci, I-41124 Modena, Italy

来源：

NANOMEDICINE | 2015年 / 10卷 / 11期

关键词：

blood-brain barrier; chitosan; drug targeting; monoclonal antibody OX26; nanoparticles; POLYMERIC NANOPARTICLES; BARRIER DISRUPTION; DELIVERY; BIODISTRIBUTION; TRANSPORT; INSIGHT; CROSS; FATE;

D O I：

10.2217/nnm.15.29

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 [微生物学]; 090105 [作物生产系统与生态工程];

摘要：

Aim: Drug targeting to the CNS is challenging due to the presence of blood-brain barrier. We investigated chitosan (Cs) nanoparticles (NPs) as drug transporter system across the blood-brain barrier, based on mAb OX26 modified Cs. Materials & methods: Cs NPs functionalized with PEG, modified and unmodified with OX26 (Cs-PEG-OX26) were prepared and chemico-physically characterized. These NPs were administered (intraperitoneal) in mice to define their ability to reach the brain. Results: Brain uptake of OX26-conjugated NPs is much higher than of unmodified NPs, because: long-circulating abilities (conferred by PEG), interaction between cationic Cs and brain endothelium negative charges and OX26 TfR receptor affinity. Conclusion: Cs-PEG-OX26 NPs are promising drug delivery system to the CNS.

引用

页码：1735 / 1750

页数：16

共 56 条

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Enhanced Antitumor Activity of the Photosensitizer meso-Tetra(N-methyl-4-pyridyl) Porphine Tetra Tosylate through Encapsulation in Antibody-Targeted Chitosan/Alginate Nanoparticles [J].