Phenotypes of major immediate-early gene mutants of mouse cytomegalovirus

被引：24

作者：

Busche, Andreas ^{[1
]}

Angulo, Ana ^{[2
]}

Kay-Jackson, Penelope ^{[1
]}

Ghazal, Peter ^{[3
]}

Messerle, Martin ^{[1
]}

机构：

[1] Hannover Med Sch, Dept Virol, D-30625 Hannover, Germany

[2] Inst Invest Biomed Augus Pi I Sunyer, Barcelona 08036, Spain

[3] Univ Edinburgh, Div Pathway Med, Edinburgh EH16 4SB, Midlothian, Scotland

来源：

MEDICAL MICROBIOLOGY AND IMMUNOLOGY | 2008年 / 197卷 / 02期

基金：

英国惠康基金;

关键词：

mouse cytomegalovirus; immediate-early genes; viral mutants; phenotypes;

D O I：

10.1007/s00430-008-0076-3

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Immediate-early (IE) genes are the first genes to be transcribed during the lytic replication cycle of cytomegaloviruses (CMV), and encode nonstructural proteins, which are assumed to have mainly regulatory functions. The IE proteins may play important roles in the pathogenesis of CMV in vivo, for instance during the establishment of latency and during reactivation. We constructed mouse CMV mutants with disruptions in the major IE genes, ie1 and ie3, to study the roles of these genes in the context of the viral infection. Here we summarize the current results on the characterization of these mutants and give a perspective of the future research in this field.

引用

页码：233 / 240

页数：8

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