Mannose-binding lectin polymorphisms in a Canary Islands (Spain) population

被引：15

作者：

García-Laorden, MI

Manzanedo, A

Figuerola, A

Sánchez-García, F

Rodríguez-Gallego, C

机构：

[1] Hosp Gran Canaria Dr Negrin, Dept Immunol, Las Palmas Gran Canaria 35020, Spain

[2] Hosp Gran Canaria Dr Negrin, Dept Prevent Med, Las Palmas Gran Canaria 35020, Spain

来源：

GENES AND IMMUNITY | 2001年 / 2卷 / 05期

关键词：

mannose-binding lectin; MBL; complement; polymorphisms; population genetics; Canarian population;

D O I：

10.1038/sj.gene.6363778

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

We have compared the structural and promoter variants of the mannose-binding lectin (MBL) gene in a population from Gran Canaria with that from other populations previously reported. The observed frequencies of the seven alleles of the MBL gene in our population were: HYPA, 0.24; LYQA, 0.22; LYPA, 0.08; LXPA, 0.19; LYPB, 0.17; LYQC, 0.03 and HYPD, 0.07. The frequency of non-producer alleles and of MBL-deficient individuals in our population is higher than in other European and Asian population.

引用

页码：292 / 294

页数：3

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