Aiding and abetting roles of NOX oxidases in cellular transformation

被引：240

作者：

Block, Karen ^{[1
,2
]}

Gorin, Yves ^{[2
]}

机构：

[1] S Texas Vet Hlth Care Syst, Audie L Murphy Mem Hosp Div, Dept Med MC 7882, San Antonio, TX 78229 USA

[2] Univ Texas Hlth Sci Ctr San Antonio, Dept Med MC 7882, San Antonio, TX 78229 USA

来源：

NATURE REVIEWS CANCER | 2012年 / 12卷 / 09期

关键词：

GENERATING NADPH OXIDASE; ADENINE-DINUCLEOTIDE PHOSPHATE; ACTIVATE SUPEROXIDE GENERATION; OXYGEN SPECIES GENERATION; TUMOR-SUPPRESSOR PROTEIN; BREAST-CANCER CELLS; REACTIVE OXYGEN; NAD(P)H OXIDASE; GROWTH-FACTOR; OXIDATIVE STRESS;

D O I：

10.1038/nrc3339

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

NADPH oxidases of the NADPH oxidase (NOX) family are dedicated reactive oxygen species-generating enzymes that broadly and specifically regulate redox-sensitive signalling pathways that are involved in cancer development and progression. They act at specific cellular membranes and microdomains through the activation of oncogenes and the inactivation of tumour suppressor proteins. In this Review, we discuss primary targets and redox-linked signalling systems that are influenced by NOX-derived ROS, and the biological role of NOX oxidases in the aetiology of cancer.

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收藏

页码：627 / 637

页数：11

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