Protein translocation across membranes

被引:85
作者
Agarraberes, FA [1 ]
Dice, JF [1 ]
机构
[1] Tufts Univ, Sch Med, Sackler Sch Grad Biomed Sci, Dept Cellular & Mol Physiol, Boston, MA 02111 USA
来源
BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES | 2001年 / 1513卷 / 01期
关键词
protein; translocation; membranes;
D O I
10.1016/S0304-4157(01)00005-3
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Cellular membranes act as semipermeable barriers to ions and macromolecules. Specialized mechanisms of transport of proteins across membranes have been developed during evolution. There are common mechanistic themes among protein translocation systems in bacteria and in eukaryotic cells. Here we review current understanding of mechanisms of protein transport across the bacterial plasma membrane as well as across several organelle membranes of yeast and mammalian cells. We consider a variety of organelles including the endoplasmic reticulum, outer and inner membranes of mitochondria, outer, inner, and thylakoid membranes of chloroplasts, peroxisomes. and lysosomes. Several common principles are evident: (a) multiple pathways of protein translocation across membranes exist, (b) molecular chaperones are required in the cytosol, inside the organelle, and often within the organelle membrane, (c) ATP and/or GTP hydrolysis is required, (d) a protonmotive force across the membrane is often required, and (e) protein translocation occurs through gated, aqueous channels. There are exceptions to each of these common principles indicating that our knowledge of how proteins translocate across membranes is not yet complete. (C) 2001 Elsevier Science B.V. All rights reserved.
引用
收藏
页码:1 / 24
页数:24
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