Human ileal bile acid-binding protein promoter and the effects of CDX2

被引：9

作者：

Barley, NF ^{[1
]}

Taylor, V ^{[1
]}

Shaw-Smith, CJ ^{[1
]}

Chakravarty, P ^{[1
]}

Howard, A ^{[1
]}

Legon, S ^{[1
]}

Walters, JRF ^{[1
]}

机构：

[1] Univ London Imperial Coll Sci Technol & Med, Fac Med, Gastroenterol Sect, London W12 0NN, England

来源：

BIOCHIMICA ET BIOPHYSICA ACTA-GENE STRUCTURE AND EXPRESSION | 2003年 / 1630卷 / 2-3期

基金：

英国生物技术与生命科学研究理事会; 英国惠康基金;

关键词：

FABP6; bile salt; intestinal absorption; transcription factor; FXR;

D O I：

10.1016/j.bbaexp.2003.09.008

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The ileal bile acid-binding protein (IBABP) is important for the reabsorption of bile salts in the distal small intestine. Studies with the human IBABP gene (FABP6, on chromosome 5q33.3-q34) defined the major transcription start site and identified conserved elements. A consensus element for the caudal-related homeobox factor CDX2 was functional in gel-shift assays and in transfection experiments. (C) 2003 Elsevier B.V. All rights reserved.

引用

收藏

页码：138 / 143

页数：6

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