An approach to enhance specificity against RNA targets using heteroconjugates of aminoglycosides and chloramphenicol (or linezolid)

被引：45

作者：

Lee, JK

Kwon, MY

Lee, KH

Jeong, SJ

Hyun, S

Shin, KJ

Yu, JH

机构：

[1] Korea Inst Sci & Technol, Div Life Sci, Seoul 130650, South Korea

[2] Dankook Univ, Coll Nat Sci, Dept Mol Biol, Seoul 140714, South Korea

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2004年 / 126卷 / 07期

关键词：

D O I：

10.1021/ja038937y

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

We describe the design and synthesis of new heterodimeric conjugates, which are comprised of a neomycin B (Neo) stem-binding component and a chloramphenicol (Cam) or linezolid (Lnz) loop-binding component. Some of the heterodimeric conjugates display enhanced affinities to RNA targets and that binding occurs in both stem and loop regions of the RNA. In addition, the results of foot-printing and mutation studies suggest that the enhanced binding affinity of the conjugates is RNA sequence-specific. Copyright © 2004 American Chemical Society.

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页码：1956 / 1957

页数：2

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