Novel approaches for the treatment of rheumatoid arthritis: lessons from the evaluation of synovial biomarkers in clinical trials

被引：50

作者：

Gerlag, Danielle M. ^{[1
]}

Tak, Paul P. ^{[1
]}

机构：

[1] Univ Amsterdam, Acad Med Ctr, Div Clin Immunol & Rheumatol, NL-1105 AZ Amsterdam, Netherlands

来源：

BEST PRACTICE & RESEARCH IN CLINICAL RHEUMATOLOGY | 2008年 / 22卷 / 02期

关键词：

anti-TNF treatment; biomarkers; chemokine receptors; chemokines; rheumatoid arthritis; rituximab; synovial tissue; treatment;

D O I：

10.1016/j.berh.2008.02.002

中图分类号：

R5 [内科学];

学科分类号：

1002 [临床医学]; 100201 [内科学];

摘要：

The analysis of synovial biomarkers is increasingly used in the context of innovative trial design in rheumatoid arthritis (RA). This approach, which is generally well tolerated by patients, has been used to provide insight into the pathogenesis of RA and the mechanism of action of therapy, as well as for screening purposes during early drug development.

引用

页码：311 / 323

页数：13

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