A mouse model of metabolic syndrome; Increase in visceral adipose tissue precedes the development of fatty liver and insulin resistance in high-fat diet-fed male KK/Ta mice

被引：75

作者：

Akagiri, Satomi ^{[1
]}

Naito, Yuji ^{[1
]}

Ichikawa, Hiroshi ^{[2
]}

Mizushima, Katsura ^{[1
]}

Takagi, Tomohisa ^{[1
]}

Handa, Osamu ^{[1
]}

Kokura, Satoshi ^{[1
]}

Yoshikawa, Toshikazu ^{[1
]}

机构：

[1] Kyoto Prefectural Univ Med, Kyoto 6028566, Japan

[2] Kyoto Prefectural Univ, Fac Human Environm, Dept Food Sci & Nutr Hlth, Kyoto 6028522, Japan

来源：

JOURNAL OF CLINICAL BIOCHEMISTRY AND NUTRITION | 2008年 / 42卷 / 02期

关键词：

metabolic syndrome; high-fat diet; white adipose tissue; fatty liver;

D O I：

10.3164/jcbn.2008022

中图分类号：

R15 [营养卫生、食品卫生]; TS201 [基础科学];

学科分类号：

100403 ;

摘要：

To determine the relative contribution of obesity and visceral white adipose tissue (WAT) to metabolic syndrome, we developed a model that is susceptible to high-fat diet-induced obesity and insulin resistance using male KK/Ta mice. The ratio of WAT weight to body weight was greater in the high-fat diet group compared with the control group in 10-, 14-, and 22-week-old mice. The increase in visceral WAT preceded development of fatty liver and insulin resistance. Adiponectin mRNA expression in WAT was markedly decreased before the decrease in its plasma levels or the development of insulin resistance. Insulin resistance appeared in association with fatty infiltration and TNF-alpha expression in the liver in 22-week-old mice. These data indicate that our mouse model would be useful for future studies that investigate the role of visceral WAT and its products in the development of metabolic syndrome.

引用

页码：150 / 157

页数：8

共 18 条

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