Synthesis of 3′-1,2,4-triazolo- and 3′-1,3,4-thiadiazoliminothymidines

被引：11

作者：

Al-Soud, YA

Al-Masoudi, NA

机构：

[1] Univ Konstanz, Fak Chem, D-78457 Constance, Germany

[2] Univ Al Al Bayt, Coll Sci, Dept Chem, Al Mafraq, Jordan

来源：

HETEROATOM CHEMISTRY | 2003年 / 14卷 / 04期

关键词：

1-AZA-2-AZONIAALLENE CATIONS; ANTIVIRAL ACTIVITY; NUCLEOSIDES; SALTS; AZO;

D O I：

10.1002/hc.10146

中图分类号：

O6 [化学];

学科分类号：

070301 [无机化学];

摘要：

New 5'-acetyl-3'-1,3,4-thiadiazolimino-thymidines 11, 14 were prepared, via spontaneous rearrangments, by cycloaddition of 5'-acetyl-3'-deoxy-3'-isothiocyanato-thymidine 9 with 1-aza-2-azoniaallene hexachloantimonates. Similary, 3'-cyano analogue 19 was reacted with the same cumulenes to furnish 3'-1,2,4-triazolo-thymidines 22, 24, and 26. Deblocking of the acylated products afforded the free nucleosides. (C) 2003 Wiley Periodicals, Inc.

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页码：298 / 303

页数：6

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