Nonself-antigens are the cognate Specificities of Foxp3+ regulatory T cells

被引:160
作者
Pacholczyk, Rafal [1 ]
Kern, Joanna
Singh, Nagendra
Iwashima, Makio
Kraj, Piotr
Lgnatowicz, Leszek
机构
[1] Med Coll Georgia, Ctr Biotechnol & Genom Med, Augusta, GA 30912 USA
[2] Med Coll Georgia, Immunotherapy Ctr, Augusta, GA 30912 USA
关键词
D O I
10.1016/j.immuni.2007.07.019
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
The majority of regulatory Foxp3(+)CD4(+) T cells naturally arises in the thymus. It has been proposed that T cell receptors (TCRs) on these cells recognize self-MHC class II-peptide complexes with high or higher affinity and that their specificities mirror specificities of autoreactive T cells. Here, we analyzed hundreds of TCRs derived from regulatory or nonregulatory T cells and found little evidence that the former population preferably recognizes self-antigens as agonists. Instead, these cells recognized foreign MHC-peptide complexes as often as nonregulatory T cells. Our results show that high-affinity, autoreactive TCRs are rare on all CD4(+) T cells and suggest that selecting self-peptide is different from the peptide that activates the same regulatory T cells in the periphery.
引用
收藏
页码:493 / 504
页数:12
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