Highly diastereoselective ortho-lithiation of 1,1'-bis-(oxazolinyl)ferrocene directed to C-2-symmetric chiral ligands

被引：117

作者：

Zhang, WB

Adachi, Y

Hirao, T

Ikeda, I

机构：

[1] Department of Applied Chemistry, Faculty of Engineering, Osaka University, Suita

来源：

TETRAHEDRON-ASYMMETRY | 1996年 / 7卷 / 02期

关键词：

D O I：

10.1016/0957-4166(96)00028-6

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

C-2-Symmetric 1, 1', 2, 2'-tetrasubstituted ferrocene derivatives are prepared in high yields from chiral 1, 1'-bis(oxazolinyl)ferrocenes via diastereoselective o, o'-dilithiation with sec-butyllithium followed by nucleophilic substitution. 1, 1'-Bis(oxazolinyl)ferrocenes were prepared from 1, 1'-ferrocenedicarbonyl dichloride and enantiomerically pure aminoalcohols via the corresponding bis(beta-hydroxylamide)s and dimesylates as intermediates.

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页码：451 / 460

页数：10

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