Postnatal exposure to chlorinated dioxins and related chemicals on thyroid hormone status in Japanese breast-fed infants

被引：72

作者：

Nagayama, J ^{[1
]}

Okamura, K

Iida, T

Hirakawa, H

Matsueda, T

Tsuji, H

Hasegawa, M

Sato, K

Ma, HY

Yanagawa, T

Igarashi, H

Fukushige, J

Watanabe, T

机构：

[1] Kyushu Univ, Sch Hlth Sci, Environm Hlth Sci Lab, Fukuoka 812, Japan

[2] Kyushu Univ, Sch Hlth Sci, Clin Chem Lab, Fukuoka 812, Japan

[3] Fukuoka Inst Hlth & Environm Sci, Dept Environm Sci, Fukuoka 81801, Japan

[4] Kyushu Univ, Fac Med, Dept Internal Med 2, Fukuoka 812, Japan

[5] Kyushu Univ, Sch Hlth Sci, Dept Midwifery, Fukuoka 812, Japan

[6] Kyushu Univ, Fac Sci, Dept Math Stat, Fukuoka 812, Japan

[7] Kyushu Univ, Fac Med, Dept Pediat, Fukuoka 812, Japan

[8] Watanabe OBGY Clin, Fukuoka 813, Japan

来源：

CHEMOSPHERE | 1998年 / 37卷 / 9-12期

关键词：

lactational exposure; polychlorinated dibenzo-p-dioxins; polychlorinated dibenzofurans; coplanar PCBs; thyroid hormones; Japanese infants;

D O I：

10.1016/S0045-6535(98)00244-6

中图分类号：

X [环境科学、安全科学];

学科分类号：

08 ; 0830 ;

摘要：

Effects of postnatal exposure to polychlorinated dibenzo-p-dioxins (PCDDs), polychlorinated dibenzofurans (PCDFs) and coplanar polychlorinated biphenyls (Co-PCBs) on thyroid hormone status were studied in the peripheral blood of 36 breast-fed Japanese infants. Estimated total intakes of these chemicals in toxic equivalent quantity (TEQ) converted into 2,3,7,8-tetrachlorodibenzo-p-dioxin, (2,3,7,8-TCDD) from the breast milk significantly and negatively correlated with the levels of triiodothyronine (T-3) and thyroxine (T-4) in the blood of breast-fed babies. Therefore, exposure to background levels of the highly toxic organochlorine chemicals through the breast milk may cause some effects on thyroid hormone status in Japanese infants. (C) 1998 Elsevier Science Ltd. All rights reserved.

引用

页码：1789 / 1793

页数：5

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