Short early filling deceleration time on day 1 after acute myocardial infarction is associated with short and long term left ventricular remodelling

被引:25
作者
Otasevic, P [1 ]
Neskovic, AN [1 ]
Popovic, Z [1 ]
Vlahovic, A [1 ]
Bojic, D [1 ]
Bojic, M [1 ]
Popovic, AD [1 ]
机构
[1] Dedinje Cardiovasc Inst, Dr Aleksander S Popovic Cardiovasc Res Ctr, YU-11040 Belgrade, Yugoslavia
关键词
deceleration time; left ventricular remodelling; acute myocardial infarction;
D O I
10.1136/heart.85.5.527
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Objective--To assess the relations between early filling deceleration time, left ventricular remodelling, and cardiac mortality in an unselected group of postinfarction patients. Design and patients-Prospective evaluation of 131 consecutive patients with first acute myocardial infarction. Echocardiography was performed on day l,day 2, day 3, day 7, at three and six weeks, and at three, six, and 12 months after infarction. According to deceleration time on day 1, patients were divided into groups with short (< 150 ms) and normal deceleration time (greater than or equal to 150 ms). Setting--Tertiary care centre. Results--Patients with a short deceleration time had higher end systolic and end diastolic volume indices and a higher wall motion score index, but a lower ejection fraction, in the year after infarction. These patients also showed a significant increase in end diastolic (p < 0.001) and end systolic volume indices (p = 0.007) during the follow up period, while ejection fraction and wall motion score index remained unchanged. In the group with normal deceleration time, end diastolic volume index increased (p <less than> 0.001) but end systolic volume index did not change; in addition, the ejection fraction increased (p = 0.002) and the wall motion score index decreased (p < 0.001). One year and five year survival analysis showed greater cardiac mortality in patients with a short deceleration time (p = 0.04 and p = 0.02, respectively). In a Cox model, which included initial ejection fraction, infarct location, and infarct size, deceleration time on day 1 was the only significant predictor of five year mortality. Conclusions--A Short deceleration time on day 1 after acute myocardial infarction can identify patients who are likely to undergo left ventricular remodelling in the following year. These patients have a higher one year and five year cardiac mortality.
引用
收藏
页码:527 / 532
页数:6
相关论文
共 26 条
  • [1] Randomized comparison of coronary thrombolysis achieved with double-bolus reteplase (Recombinant plasminogen activator) and front-loaded, accelerated alteplase (Recombinant tissue plasminogen activator) in patients with acute myocardial infarction
    Bode, C
    Smalling, RW
    Berg, G
    Burnett, C
    Lorch, G
    Kalbfleisch, JM
    Chernoff, R
    Christie, LG
    Feldman, RL
    Seals, AA
    Weaver, WD
    [J]. CIRCULATION, 1996, 94 (05) : 891 - 898
  • [2] Doppler-derived mitral deceleration time - An early strong predictor of left ventricular remodeling after reperfused anterior acute myocardial infarction
    Cerisano, G
    Bolognese, L
    Carrabba, N
    Buonamici, P
    Santoro, GM
    Antoniucci, D
    Santini, A
    Moschi, G
    Fazzini, PF
    [J]. CIRCULATION, 1999, 99 (02) : 230 - 236
  • [3] CHOONG CY, 1994, PRINCIPLES PRACTICE, P721
  • [4] MEDICAL THERAPY OF ACUTE MYOCARDIAL-INFARCTION BY APPLICATION OF HEMODYNAMIC SUBSETS .1.
    FORRESTER, JS
    DIAMOND, G
    CHATTERJEE, K
    SWAN, HJC
    [J]. NEW ENGLAND JOURNAL OF MEDICINE, 1976, 295 (24) : 1356 - 1362
  • [5] Independent and incremental prognostic value of Doppler-derived mitral deceleration time of early filling in both symptomatic and asymptomatic patients with left ventricular dysfunction
    Giannuzzi, P
    Temporelli, PL
    Bosimini, E
    Silva, P
    Imparato, A
    Corra, U
    Galli, M
    Giordano, A
    [J]. JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 1996, 28 (02) : 383 - 390
  • [6] DOPPLER-DERIVED MITRAL DECELERATION TIME OF EARLY FILLING AS A STRONG PREDICTOR OF PULMONARY CAPILLARY WEDGE PRESSURE IN POSTINFARCTION PATIENTS WITH LEFT-VENTRICULAR SYSTOLIC DYSFUNCTION
    GIANNUZZI, P
    IMPARATO, A
    TEMPORELLI, PL
    DEVITO, F
    SILVA, PL
    SCAPELLATO, F
    GIORDANO, A
    [J]. JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 1994, 23 (07) : 1630 - 1637
  • [7] HOCHMAN JS, 1997, TXB CARDIOVASCULAR M, P437
  • [8] INFLUENCE OF MYOCARDIAL-INFARCTION SIZE ON RADIONUCLIDE AND DOPPLER ECHOCARDIOGRAPHIC MEASUREMENTS OF DIASTOLIC FUNCTION
    JOHANNESSEN, KA
    CERQUEIRA, MD
    STRATTON, JR
    [J]. AMERICAN JOURNAL OF CARDIOLOGY, 1990, 65 (11) : 692 - 697
  • [9] INTRAVENOUS NITROGLYCERIN THERAPY TO LIMIT MYOCARDIAL INFARCT SIZE, EXPANSION, AND COMPLICATIONS - EFFECT OF TIMING, DOSAGE, AND INFARCT LOCATION
    JUGDUTT, BI
    WARNICA, JW
    [J]. CIRCULATION, 1988, 78 (04) : 906 - 919
  • [10] POTENTIAL BENEFITS OF LATE REPERFUSION OF INFARCTED MYOCARDIUM - THE OPEN ARTERY HYPOTHESIS
    KIM, CB
    BRAUNWALD, E
    [J]. CIRCULATION, 1993, 88 (05) : 2426 - 2436