CD8 T cell dysfunction during chronic viral infection

被引：285

作者：

Shin, Haina ^{[1
]}

Wherry, E. John ^{[1
]}

机构：

[1] Wistar Inst Anat & Biol, Program Immunol, Philadelphia, PA 19104 USA

来源：

CURRENT OPINION IN IMMUNOLOGY | 2007年 / 19卷 / 04期

关键词：

D O I：

10.1016/j.coi.2007.06.004

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Clearance of primary infection often leads to the development of highly functional memory T cells capable of rapid and long-lasting protective immunity. By contrast, chronic infections can result in T cell dysfunction and poor pathogen control. In this review, we will discuss recent work that highlights two main types of T cell dysfunction during chronic infection: exhaustion of effector functions and altered memory T cell development.

引用

页码：408 / 415

页数：8

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