HLA-DRB103, DRB111 or DRB1*12 and their respective DRB3 specificities in clinical variants of sarcoidosis

被引：61

作者：

Bogunia-Kubik, K

Tomeczko, J

Suchnicki, K

Lange, A

机构：

[1] Polish Acad Sci, L Hirszfeld Inst Immunol & Expt Therapy, PL-53114 Wroclaw, Poland

[2] K Diuski Hosp, Div Immunotherapy & Bone Marrow Transplantat, Wroclaw, Poland

来源：

TISSUE ANTIGENS | 2001年 / 57卷 / 01期

关键词：

DRB1; DRB3; Lofgren's syndrome; sarcoidosis;

D O I：

10.1034/j.1399-0039.2001.057001087.x

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Determination of DRB1 and DRB3 specificities in sarcoidosis patients identified that the presence of DRB1*03 and the absence of DRB1*11 and/or DRB1*12 favors a course of disease that is associated positively with Lofgren's syndrome (DRB1*03) and negatively with stage I disease (DRB1*11 and/or 12). In common with normal controls, DRB1*03 was associated with DRB3*0101 and DRB1*11/12 with DRB3*0201/2. An analysis of DRB1 and DRB3 associations in Variants of sarcoidosis revealed that DRB1*03 and DRB3*0101 were associated with Lofgren's syndrome in a combined association fashion, Conversely, a lack of DRB1*11 and/or DRB1*12 but not DRB3*0201/2 favored the clinical course of sarcoidosis.

引用

页码：87 / 90

页数：4

共 12 条

[1] ASSOCIATION OF HLA-DR WITH SARCOIDOSIS - CORRELATION WITH CLINICAL COURSE [J].

ABE, S ;

YAMAGUCHI, E ;

MAKIMURA, S ;

OKAZAKI, N ;

KUNIKANE, H ;

KAWAKAMI, Y .

CHEST, 1987, 92 (03) :488-490

[2]

BALLAS M, 1992, HLA 1991, V2, P311

[3]

CRYSTAL RG, 1991, HARRISONS PRINCIPLES, P1463

[4] SARCOIDOSIS AND MAJOR HISTOCOMPATIBILITY COMPLEX GENES WITH SPECIAL EMPHASIS ON BF F SUBTYPES [J].

FINCO, O ;

MARTINETTI, M ;

DONDI, E ;

LUISETTI, M ;

PASTURENZI, L ;

CUCCIA, M .

COMPLEMENT AND INFLAMMATION, 1991, 8 (02) :80-85

[5] HLA ASSOCIATIONS IN SARCOIDOSIS - A STUDY OF 2 ETHNIC-GROUPS [J].

GARDNER, J ;

KENNEDY, HG ;

HAMBLIN, A ;

JONES, E .

THORAX, 1984, 39 (01) :19-22

[6]

HEDFORS E, 1983, TISSUE ANTIGENS, V22, P200

[7] MOLECULAR-GENETIC STUDIES OF HLA CLASS-II ALLELES IN SARCOIDOSIS [J].

ISHIHARA, M ;

OHNO, S ;

ISHIDA, T ;

ANDO, H ;

NARUSE, T ;

NOSE, Y ;

INOKO, H .

TISSUE ANTIGENS, 1994, 43 (04) :238-241

[8]

KRAUSE A, 1987, J CLIN LAB IMMUNOL, V24, P25

[9] HLA TYPING BY DOUBLE ARMS [J].

LO, YMD ;

MEHAL, WZ ;

WORDSWORTH, BP ;

CHAPMAN, RW ;

FLEMING, KA ;

BELL, JI ;

WAINSCOAT, JS .

LANCET, 1991, 338 (8758) :65-66

[10]

ODUM N, 1991, EXP CLIN IMMUNOGENET, V8, P227

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HLA-DRB1*03, DRB1*11 or DRB1*12 and their respective DRB3 specificities in clinical variants of sarcoidosis

HLA-DRB103, DRB111 or DRB1*12 and their respective DRB3 specificities in clinical variants of sarcoidosis