Investigation of an LDLR gene polymorphism (19p13.2) in susceptibility to migraine without aura

被引：23

作者：

Mochi, M

Cevoli, S

Cortelli, P

Pierangeli, G

Scapoli, C

Soriani, S

Montagna, P

机构：

[1] Univ Bologna, Dept Neurol Sci, Sch Med, Neurol Clin, I-40123 Bologna, Italy

[2] Univ Modena, Dept Neurol, Modena, Italy

[3] Osped Reggio Emilia, Modena, Italy

[4] Univ Ferrara, Dept Biol, I-44100 Ferrara, Italy

[5] Univ Ferrara, Inst Pediat, I-44100 Ferrara, Italy

来源：

JOURNAL OF THE NEUROLOGICAL SCIENCES | 2003年 / 213卷 / 1-2期

关键词：

migraine; genetics; association study; LDL receptor; chromosome; 19;

D O I：

10.1016/S0022-510X(03)00124-2

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

We performed a genetic association study with the LDL receptor gene (LDLR) on chromosome 19p 13.2 in 360 migraine patients, 220 with migraine without aura (MO) and 140 with migraine with aura (MA), and 200 controls, by analysing two polymorphic markers, a G142A transition in exon 10 and a triallelic (TA)n repeat in exon IS. The allelic distribution of the (TA)n polymorphism was significantly different between migraine without aura (MO) and both controls and migraine with aura (MA). We suggest a possible predisposition to MO in the studied population through this polymorphism or another polymorphism in linkage disequilibrium with (TA)n. (C) 2003 Elsevier Science B.V. All rights reserved.

引用

页码：7 / 10

页数：4

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