Duplex pinching: A structural switch suitable for contractile DNA nanoconstructions

被引：40

作者：

Fahlman, RP ^{[1
]}

Hsing, M ^{[1
]}

Sporer-Tuhten, CS ^{[1
]}

Sen, D ^{[1
]}

机构：

[1] Simon Fraser Univ, Dept Mol Biol & Biochem, Burnaby, BC V5A 1S6, Canada

来源：

NANO LETTERS | 2003年 / 3卷 / 08期

关键词：

D O I：

10.1021/nl034267i

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A versatile role for guanine-guanine mismatches within DNA double helices such as the formation of specific, interhelical synaptic events has previously been reported. Here, we demonstrate that certain categories of guanine-guanine mismatches within double helices enable a different structural/conformational transition-a reversible, intramolecular "pinching" of the duplex, initiated and reversed by the binding and dissociation of certain specific cations. Such a "pinching" transition should provide a valuable "contractile" feature to the design of new, DNA-based molecular motors and nanoconstructions.

引用

页码：1073 / 1078

页数：6

共 42 条

[1] DNA duplex-quadruplex exchange as the basis for a nanomolecular machine [J].

Alberti, P ;

Mergny, JL .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2003, 100 (04) :1569-1573

[2] Organization of 'nanocrystal molecules' using DNA [J].

Alivisatos, AP ;

Johnsson, KP ;

Peng, XG ;

Wilson, TE ;

Loweth, CJ ;

Bruchez, MP ;

Schultz, PG .

NATURE, 1996, 382 (6592) :609-611

[3] DNA-templated assembly and electrode attachment of a conducting silver wire [J].

Braun, E ;

Eichen, Y ;

Sivan, U ;

Ben-Yoseph, G .

NATURE, 1998, 391 (6669) :775-778

[4] ACID-FACILITATED SUPRAMOLECULAR ASSEMBLY OF G-QUADRUPLEXES IN D(CGG)(4) [J].

CHEN, FM .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1995, 270 (39) :23090-23096

[5] SR2+ FACILITATES INTERMOLECULAR G-QUADRUPLEX FORMATION OF TELOMERIC SEQUENCES [J].

CHEN, FM .

BIOCHEMISTRY, 1992, 31 (15) :3769-3776

[6] SYNTHESIS FROM DNA OF A MOLECULE WITH THE CONNECTIVITY OF A CUBE [J].

CHEN, JH ;

SEEMAN, NC .

NATURE, 1991, 350 (6319) :631-633

[7] Synapsable DNA double helices: Self-selective modules for assembling DNA superstructures [J].

Fahlman, RP ;

Sen, D .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1999, 121 (48) :11079-11085

[8] DNA conformational switches as sensitive electronic sensors of analytes [J].

Fahlman, RP ;

Sen, D .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2002, 124 (17) :4610-4616

[9] Cation-regulated self-association of "synapsable" DNA duplexes [J].

Fahlman, RP ;

Sen, D .

JOURNAL OF MOLECULAR BIOLOGY, 1998, 280 (02) :237-244

[10]

Jaeger L, 2000, ANGEW CHEM INT EDIT, V39, P2521, DOI 10.1002/1521-3773(20000717)39:14<2521::AID-ANIE2521>3.0.CO

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