The immunomodulatory properties of mesenchymal stem cells and their use for immunotherapy

被引：225

作者：

Hoogduijn, Martin J. ^{[1
]}

Popp, Felix ^{[2
]}

Verbeek, Richard ^{[3
]}

Masoodi, Mojgan ^{[4
]}

Nicolaou, Anna ^{[4
,5
]}

Baan, Carla ^{[1
]}

Dahlke, Marc-H ^{[2
]}

机构：

[1] Erasmus Univ, Med Ctr, Dept Internal Med, Rotterdam, Netherlands

[2] Univ Regensburg, Dept Surg, D-8400 Regensburg, Germany

[3] Delta Cell, Leiden, Netherlands

[4] Bradford Sch Pharm, Bradford, W Yorkshire, England

[5] Univ Bradford, Sch Life Sci, Ctr Skin Sci, Bradford BD7 1DP, W Yorkshire, England

来源：

INTERNATIONAL IMMUNOPHARMACOLOGY | 2010年 / 10卷 / 12期

关键词：

Mesenchymal stem cells; Immunomodulation; Cytokines; Prostaglandins; Immune therapy; Organ transplantation; VERSUS-HOST-DISEASE; PROLIFERATION IN-VITRO; REGULATORY T-CELLS; STROMAL CELLS; ADIPOSE-TISSUE; IFN-GAMMA; HUMAN HEART; RESPONSES; INHIBIT; TRANSPLANTATION;

D O I：

10.1016/j.intimp.2010.06.019

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

071005 [微生物学]; 100108 [医学免疫学];

摘要：

There is growing interest in the use of mesenchymal stem cells (MSC) for immune therapy. Clinical trials that use MSC for treatment of therapy resistant graft versus host disease, Crohn's disease and organ transplantation have initiated. Nevertheless, the immunomodulatory effects of MSC are only partly understood. Clinical trials that are supported by basic research will lead to better understanding of the potential of MSC for immunomodulatory applications and to optimization of such therapies. In this manuscript we review some recent literature on the mechanisms of immunomodulation by MSC in vitro and animal models, present new data on the secretion of pro-inflammatory and anti-inflammatory cytokines, chemokines and prostaglandins by MSC under resting and inflammatory conditions and discuss the hopes and expectations of MSC-based immune therapy. (C) 2010 Elsevier B.V. All rights reserved.

引用

页码：1496 / 1500

页数：5

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