Nucleic-acid-chaperone activity of retroviral nucleocapsid proteins: significance for viral replication

被引：339

作者：

Rein, A ^{[1
]}

Henderson, LE

Levin, JG

机构：

[1] NCI, Frederick Canc Res & Dev Ctr, ABL Basic Res Program, Retroviral Genet Sect, Frederick, MD 21702 USA

[2] NCI, Frederick Canc Res & Dev Ctr, AIDS Vaccine Program, SAIC Frederick, Frederick, MD 21702 USA

[3] NICHHD, Mol Genet Lab, NIH, Bethesda, MD 20892 USA

来源：

TRENDS IN BIOCHEMICAL SCIENCES | 1998年 / 23卷 / 08期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1016/S0968-0004(98)01256-0

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Retrovirus particles contain a small, basic protein, the nucleocapsid (NC) protein, that possesses 'nucleic acid chaperone' activity - that is, the NC protein can catalyze the rearrangement of a nucleic acid molecule into the conformation that has the maximal number of base pairs. The molecular mechanism that underlies this effect is not understood. Because the chaperone activity is apparently crucial during the infectious process, NC is a potential target for antiviral therapy.

引用

页码：297 / 301

页数：5

共 54 条

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