Self-organization of treadmilling filaments

被引:23
作者
Doubrovinski, K. [1 ]
Kruse, K.
机构
[1] Univ Saarland, Fachrichtung Theoret Phys, D-66041 Saarbrucken, Germany
[2] Max Planck Inst Phys Komplexer Syst, D-01187 Dresden, Germany
关键词
D O I
10.1103/PhysRevLett.99.228104
中图分类号
O4 [物理学];
学科分类号
0702 ;
摘要
The cytoskeleton is an active network of polar filaments. The activity can lead to the polymerization of filaments at one end and depolymerization at the other. This phenomenon is called treadmilling and is essential for many cellular processes, in particular, the crawling of cells on a substrate. We develop a microscopic theoretical framework for describing systems of treadmilling filaments. We show that such systems can self-organize into structures observed in cell fragments, in particular, asters and moving spots.
引用
收藏
页数:4
相关论文
共 22 条
[1]  
[Anonymous], 2001, MECH MOTOR PROTEINS
[2]   Pattern formation of microtubules and motors: Inelastic interaction of polar rods [J].
Aranson, IS ;
Tsimring, LS .
PHYSICAL REVIEW E, 2005, 71 (05)
[3]   Active gels: dynamics of patterning and self-organization [J].
Backouche, F. ;
Haviv, L. ;
Groswasser, D. ;
Bernheim-Groswasser, A. .
PHYSICAL BIOLOGY, 2006, 3 (04) :264-273
[4]  
Bray D., 2001, Cell Movements: From Molecules to Motility, V2nd
[5]   Computational model of dynein-dependent self-organization of microtubule asters [J].
Cytrynbaum, EN ;
Rodionov, V ;
Mogilner, A .
JOURNAL OF CELL SCIENCE, 2004, 117 (08) :1381-1397
[6]   PHYSICAL ASPECTS OF THE GROWTH AND REGULATION OF MICROTUBULE STRUCTURES [J].
DOGTEROM, M ;
LEIBLER, S .
PHYSICAL REVIEW LETTERS, 1993, 70 (09) :1347-1350
[7]   Actively contracting bundles of polar filaments [J].
Kruse, K ;
Jülicher, F .
PHYSICAL REVIEW LETTERS, 2000, 85 (08) :1778-1781
[8]   Contractility and retrograde flow in lamellipodium motion [J].
Kruse, K. ;
Joanny, J. F. ;
Juelicher, F. ;
Prost, J. .
PHYSICAL BIOLOGY, 2006, 3 (02) :130-137
[9]   Self-organization and mechanical properties of active filament bundles -: art. no. 051913 [J].
Kruse, K ;
Jülicher, F .
PHYSICAL REVIEW E, 2003, 67 (05) :16
[10]   Continuum theory of contractile fibres [J].
Kruse, K ;
Zumdieck, A ;
Jülicher, F .
EUROPHYSICS LETTERS, 2003, 64 (05) :716-722