Evaluation of the immunomodulatory activities of royal jelly components in vitro

被引：50

作者：

Gasic, Sonja ^{[1
]}

Vucevic, Dragana ^{[1
]}

Vasilijic, Sasa ^{[1
]}

Antunovic, Mirjana ^{[3
]}

Chinou, Ioanna ^{[2
]}

Colic, Miodrag ^{[1
]}

机构：

[1] Mil Med Acad, Inst Med Res, Belgrade 11002, Serbia

[2] Univ Athens, Fac Pharm, Div Pharmacognosy & Nat Prod, Athens, Greece

[3] Mil Med Acad, Inst Pharm, Belgrade 11002, Serbia

来源：

IMMUNOPHARMACOLOGY AND IMMUNOTOXICOLOGY | 2007年 / 29卷 / 3-4期

关键词：

royal jelly; T cells; proliferation; IL-2; production; NO production;

D O I：

10.1080/08923970701690977

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

In this work the effect of different components isolated from royal jelly (RJ) was studied using an in vitro rat T-cell proliferation assay. We found that lower concentrations of MEL 174 (final water extract of RJ) and MEL 147 (3-10-dihydroxydecanoic acid) stimulated T-cell proliferation, triggered by concanavalin A (Con-A) and the process was followed by an increase in the production of interleukin-2 (IL-2). Higher concentrations of MEL 174, MEL 247 (dry powder of RJ) and MEL 138 (trans-10-hydroxydec-2enoic acid) inhibited T-cell proliferation. The inhibition of T-cell proliferation in the presence of MEL 174 was followed by a decrease in IL-2 production, which was partly abrogated by exogenous IL-2, a decrease in nitric oxide (NO) production and increased apoptosis. In conclusion, our results showed the complexity of biological activity of RJ and suggest that its water extract possesses the most potent immunomodulatory activity in vitro.

引用

页码：521 / 536

页数：16

共 36 条

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