Promoter hypermethylation - Can this change alone ever designate true tumor suppressor gene function?

被引:34
作者
Baylin, SB
Herman, JG
机构
[1] Johns Hopkins Comprehens Canc Ctr, Baltimore, MD 21231 USA
[2] Johns Hopkins Med Inst, Baltimore, MD 21231 USA
关键词
D O I
10.1093/jnci/93.9.664
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
引用
收藏
页码:664 / 665
页数:2
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共 14 条
  • [1] Aberrant methylation of gene promoters in cancer - Concepts, misconcepts, and promise
    Baylin, SB
    Belinsky, SA
    Herman, JG
    [J]. JOURNAL OF THE NATIONAL CANCER INSTITUTE, 2000, 92 (18) : 1460 - 1461
  • [2] DNA hypermethylation in tumorigenesis - epigenetics joins genetics
    Baylin, SB
    Herman, JG
    [J]. TRENDS IN GENETICS, 2000, 16 (04) : 168 - 174
  • [3] Epigenetic inactivation of RASSF14 in lung and breast cancers and malignant phenotype suppression
    Burbee, DG
    Forgacs, E
    Zöchbauer-Müller, S
    Shivakumar, L
    Fong, K
    Gao, BN
    Randle, D
    Kondo, M
    Virmani, A
    Bader, S
    Sekido, Y
    Latif, F
    Milchgrub, S
    Toyooka, S
    Gazdar, AF
    Lerman, MI
    Zabarovsky, E
    White, M
    Minna, JD
    [J]. JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE, 2001, 93 (09): : 691 - 699
  • [4] Mice deficient in the candidate tumor suppressor gene Hic1 exhibit developmental defects of structures affected in the Miller-Dieker syndrome
    Carter, MG
    Johns, MA
    Zeng, XB
    Zhou, L
    Zink, MC
    Mankowski, JL
    Donovan, DM
    Baylin, SB
    [J]. HUMAN MOLECULAR GENETICS, 2000, 9 (03) : 413 - 419
  • [5] Aberrant CpG-island methylation has non-random and tumour-type-specific patterns
    Costello, JF
    Frühwald, MC
    Smiraglia, DJ
    Rush, LJ
    Robertson, GP
    Gao, X
    Wright, FA
    Feramisco, JD
    Peltomäki, P
    Lang, JC
    Schuller, DE
    Yu, L
    Bloomfield, CD
    Caligiuri, MA
    Yates, A
    Nishikawa, R
    Huang, HJS
    Petrelli, NJ
    Zhang, XL
    O'Dorisio, MS
    Held, WA
    Cavenee, WK
    Plass, C
    [J]. NATURE GENETICS, 2000, 24 (02) : 132 - 138
  • [6] Epigenetic inactivation of a RAS association domain family protein from the lung tumour suppressor locus 3p21.3
    Dammann, R
    Li, C
    Yoon, JH
    Chin, PL
    Bates, S
    Pfeifer, GP
    [J]. NATURE GENETICS, 2000, 25 (03) : 315 - 319
  • [7] A bird's eye view of global methylation
    Eng, C
    Herman, JG
    Baylin, SB
    [J]. NATURE GENETICS, 2000, 24 (02) : 101 - 102
  • [8] ESTELLER M, 2001, IN PRESS CANC RES
  • [9] Incidence and functional consequences of hMLH1 promoter hypermethylation in colorectal carcinoma
    Herman, JG
    Umar, A
    Polyak, K
    Graff, JR
    Ahuja, N
    Issa, JPJ
    Markowitz, S
    Willson, JKV
    Hamilton, SR
    Kinzler, KW
    Kane, MF
    Kolodner, RD
    Vogelstein, B
    Kunkel, TA
    Baylin, SB
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1998, 95 (12) : 6870 - 6875
  • [10] Hypermethylation of the DAP-Kinase CpG island is a common alteration in B-cell malignancies
    Katzenellenbogen, RA
    Baylin, SB
    Herman, JG
    [J]. BLOOD, 1999, 93 (12) : 4347 - 4353