Mesp1 expression is the earliest sign of cardiovascular development

被引:182
作者
Saga, Y
Kitajima, S
Miyagawa-Tomita, S
机构
[1] Natl Inst Hlth Sci, Cellular & Mol Toxicol Div, Setagaya Ku, Tokyo 158, Japan
[2] Tokyo Womens Med Univ, Heart Inst Japan, Dept Pediat Cardiol, Shinjuku Ku, Tokyo 1628666, Japan
关键词
D O I
10.1016/S1050-1738(01)00069-X
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Understanding the molecular mechanism leading to formation of the heart and vasculature during embryogenesis is critically important because malformation of the cardiovascular system is the most frequently occurring type of birth defect. While the hearts of all vertebrates are derived from bilateral paired fields of primary mesodermal cells that are specified to the cardiac lineage during gastrulation, the mechanism for lineage restriction, and the origin of the myocardium and endocardium have not been defined. Recently, we found that a transcription factor, Mesp1, is expressed in almost all precursors of the cardiovascular system and plays an essential role in cardiac morphogenesis. Mesp1 may play a key role in the early specification for acardiac precursor cells. (Trends Cardiovasc Med 2000;10:345-352). (C) 2001, Elsevier Science Inc.
引用
收藏
页码:345 / 352
页数:8
相关论文
共 37 条
[1]   Serum response factor is essential for mesoderm formation during mouse embryogenesis [J].
Arsenian, S ;
Weinhold, B ;
Oelgeschläger, M ;
Rüther, U ;
Nordheim, A .
EMBO JOURNAL, 1998, 17 (21) :6289-6299
[2]   Abnormal blood vessel development and lethality in embryos lacking a single VEGF allele [J].
Carmeliet, P ;
Ferreira, V ;
Breier, G ;
Pollefeyt, S ;
Kieckens, L ;
Gertsenstein, M ;
Fahrig, M ;
Vandenhoeck, A ;
Harpal, K ;
Eberhardt, C ;
Declercq, C ;
Pawling, J ;
Moons, L ;
Collen, D ;
Risau, W ;
Nagy, A .
NATURE, 1996, 380 (6573) :435-439
[3]  
Chang H, 1999, DEVELOPMENT, V126, P1631
[4]  
Cleaver O, 1998, DEVELOPMENT, V125, P3905
[5]  
Constam DB, 2000, DEVELOPMENT, V127, P245
[6]   Avian serum response factor expression restricted primarily to muscle cell lineages is required for alpha-actin gene transcription [J].
Croissant, JD ;
Kim, JH ;
Eichele, G ;
Goering, L ;
Lough, J ;
Prywes, R ;
Schwartz, RJ .
DEVELOPMENTAL BIOLOGY, 1996, 177 (01) :250-264
[7]   MOLECULAR REGULATION OF ATRIOVENTRICULAR VALVULOSEPTAL MORPHOGENESIS [J].
EISENBERG, LM ;
MARKWALD, RR .
CIRCULATION RESEARCH, 1995, 77 (01) :1-6
[8]   Heterozygous embryonic lethality induced by targeted inactivation of the VEGF gene [J].
Ferrara, N ;
CarverMoore, K ;
Chen, H ;
Dowd, M ;
Lu, L ;
OShea, KS ;
PowellBraxton, L ;
Hillan, KJ ;
Moore, MW .
NATURE, 1996, 380 (6573) :439-442
[9]  
Fishman MC, 1997, DEVELOPMENT, V124, P2099
[10]  
GEORGE EL, 1993, DEVELOPMENT, V119, P1079