Frontiers in nephrology: The varied faces of natural killer cells in transplantation - Contributions to both allograft immunity and tolerance

被引:25
作者
Beilke, Joshua N.
Gill, Ronald G.
机构
[1] Univ Alberta, Surg Med Res Inst, Inst Diabet, Edmonton, AB T6G 2NB, Canada
[2] Univ Calif San Francisco, Dept Microbiol & Immunol, San Francisco, CA 94143 USA
[3] Univ Colorado, Hlth Sci Ctr, Barbara Davis Ctr, Denver, CO USA
来源
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY | 2007年 / 18卷 / 08期
关键词
D O I
10.1681/ASN.2007040423
中图分类号
R5 [内科学]; R69 [泌尿科学(泌尿生殖系疾病)];
学科分类号
1002 ; 100201 ;
摘要
Natural killer (NK) cells are recognized for providing an important early innate immune response to viral and bacteria] pathogens and for the surveillance of stressed and transformed autologous cells. However, with the exception of a pronounced role in allogeneic hematopoietic stem cell rejection, it has been challenging to ascribe the precise roles for INK cells in reactivity to tissue and solid-organ transplants. In general, NK cells initiate a rapid, proinflammatory environment that is conducive to many forms of effective immune host defense. This reactivity is often considered deleterious to allograft survival because NK cells are implicated in promoting both acute and chronic graft injury. However, more recent findings indicate that NK cells can also play a surprisingly profound role in allograft tolerance induction. This duality of function requires a reconsideration of the nature and consequence of INK cell reactivity during the allograft response. This review focuses on the differing "faces" of NK cells, especially the unexpected role of NK cells in allograft tolerance induction.
引用
收藏
页码:2262 / 2267
页数:6
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