Towards a truly integrative biology through the functional genomics of yeast

被引：50

作者：

Delneri, D

Brancia, FL

Oliver, SG

机构：

[1] Univ Manchester, Sch Biol Sci, Manchester M13 9PT, Lancs, England

[2] UMIST, Michael Barber Ctr Mass Spectrometry, Manchester M60 1QD, Lancs, England

来源：

CURRENT OPINION IN BIOTECHNOLOGY | 2001年 / 12卷 / 01期

基金：

英国惠康基金; 英国生物技术与生命科学研究理事会;

关键词：

D O I：

10.1016/S0958-1669(00)00179-8

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

A complete library of mutant Saccharomyces cerevisiae strains, each deleted for a single representative of yeast's 6000 protein-encoding genes, has been constructed. This represents a major biological resource for the study of eukaryotic functional genomics. However, yeast is also being used as a test-bed for the development of functional genomic technologies at all levels of analysis, including the transcriptome, proteome and metabolome.

引用

页码：87 / 91

页数：5

共 38 条

[1] Baganz F, 1998, YEAST, V14, P1417, DOI 10.1002/(SICI)1097-0061(199811)14:15<1417::AID-YEA334>3.3.CO
[2] 2-E
[3] Brancia FL, 2000, RAPID COMMUN MASS SP, V14, P2070, DOI 10.1002/1097-0231(20001115)14:21<2070::AID-RCM133>3.0.CO
[4] 2-G
[5] BRANCIA FL, 2001, IN PRESS ELECTROPHOR
[6] Knowledge-based analysis of microarray gene expression data by using support vector machines
Brown, MPS
Grundy, WN
Lin, D
Cristianini, N
Sugnet, CW
Furey, TS
Ares, M
Haussler, D
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2000, 97 (01) : 262 - 267
[7] Exploring redundancy in the yeast genome:: an improved strategy for use of the cre-loxP system
Delneri, D
Tomlin, GC
Wixon, JL
Hutter, A
Sefton, M
Louis, EJ
Oliver, SG
[J]. GENE, 2000, 252 (1-2) : 127 - 135
[8] Delneri D, 1999, GENETICS, V153, P1591
[9] A large-scale study of Yap1p-dependent genes in normal aerobic and H2O2-stress conditions:: the role of Yap1p in cell proliferation control in yeast
Dumond, H
Danielou, N
Pinto, M
Bolotin-Fukuhara, M
[J]. MOLECULAR MICROBIOLOGY, 2000, 36 (04) : 830 - 845
[10] Cluster analysis and display of genome-wide expression patterns
Eisen, MB
Spellman, PT
Brown, PO
Botstein, D
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1998, 95 (25) : 14863 - 14868

← 1 2 3 4 →