α-tocopheryl succinate inhibits angiogenesis by disrupting paracrine FGF2 signalling

被引：23

作者：

Neuzil, Jiri ^{[1
]}

Swettenham, Emma

Wang, Xiu-Fang

Dong, Lan-Feng

Stapelberg, Michael

机构：

[1] Griffith Univ, Sch Med Sci, Griffith Inst Hlth & Med Res, Heart Fdn Res Ctr,Apoptosis Res Grp, Southport, Qld 4222, Australia

[2] Acad Sci Czech Republ, Inst Mol Genet, Mol Therapy Grp, Prague, Czech Republic

来源：

FEBS LETTERS | 2007年 / 581卷 / 24期

基金：

澳大利亚研究理事会;

关键词：

alpha-tocopheryl succinate; FGF2; endothelial cell; angiogenesis; paracrine signalling;

D O I：

10.1016/j.febslet.2007.08.051

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 [生物化学与分子生物学]; 081704 [应用化学];

摘要：

Malignant mesothelioma (MM) cells enhanced proliferation of endothelial cells (ECs) as well as their angiogenesis in vitro by secretion of fibroblast growth factor-2 (FGF2). This effect was suppressed by pre-treating MM cells with alpha-tocopheryl succinate (alpha-TOS), which inhibited FGF2 secretion by inducing mitochondria-dependent generation of reactive oxygen species. The role of FGF2 was confirmed by its down-regulation by treating MM cells with siRNA, abolishing EC proliferation and wound healing enhancement afforded by MM cells. We conclude that alpha-TOS disrupts angiogenesis mediated by MM cells by inhibiting FGF2 paracrine signalling. (c) 2007 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.

引用

页码：4611 / 4615

页数：5

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