Mitochondrial control of the NLRP3 inflammasome

被引：142

作者：

Kepp, Oliver ^{[1
,2
,3
]}

Galluzzi, Lorenzo ^{[1
,2
,3
]}

Kroemer, Guido ^{[2
,4
,5
,6
,7
]}

机构：

[1] INSERM, U848, Villejuif, France

[2] Inst Gustave Roussy, Villejuif, France

[3] Univ Paris 11, Villejuif, France

[4] INSERM, U84s8, Villejuif, France

[5] Ctr Rech Cordeliers, Paris, France

[6] Hop Europeen Georges Pompidou, Paris, France

[7] Univ Paris 05, Paris, France

来源：

NATURE IMMUNOLOGY | 2011年 / 12卷 / 03期

关键词：

CELL-DEATH; AUTOPHAGY; IMMUNITY; PROTEIN;

D O I：

10.1038/ni0311-199

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

During the past few decades, the vital and lethal functions of mitochondria have been investigated extensively. Data now demonstrate that these organelles also regulate the innate immune response by modulating inflammasome-mediated generation of proinflammatory cytokines.

引用

页码：199 / 200

页数：2

共 12 条

[1] Innate immune activation through Nalp3 inflammasome sensing of asbestos and silica [J].

Dostert, Catherine ;

Petrilli, Virginie ;

Van Bruggen, Robin ;

Steele, Chad ;

Mossman, Brooke T. ;

Tschopp, Jurg .

SCIENCE, 2008, 320 (5876) :674-677

[2] Bacterial Invasion: Linking Autophagy and Innate Immunity [J].

Galluzzi, Lorenzo ;

Kepp, Oliver ;

Zitvogel, Laurence ;

Kroemer, Guido .

CURRENT BIOLOGY, 2010, 20 (03) :R106-R108

[3] The roles of TLRs, RLRs and NLRs in pathogen recognition [J].

Kawai, Taro ;

Akira, Shizuo .

INTERNATIONAL IMMUNOLOGY, 2009, 21 (04) :317-337

[4] Mitochondrial membrane permeabilization in cell death [J].

Kroemer, Guido ;

Galluzzi, Lorenzo ;

Brenner, Catherine .

PHYSIOLOGICAL REVIEWS, 2007, 87 (01) :99-163

[5] Autophagy proteins regulate innate immune responses by inhibiting the release of mitochondrial DNA mediated by the NALP3 inflammasome [J].

Nakahira, Kiichi ;

Haspel, Jeffrey Adam ;

Rathinam, Vijay A. K. ;

Lee, Seon-Jin ;

Dolinay, Tamas ;

Lam, Hilaire C. ;

Englert, Joshua A. ;

Rabinovitch, Marlene ;

Cernadas, Manuela ;

Kim, Hong Pyo ;

Fitzgerald, Katherine A. ;

Ryter, Stefan W. ;

Choi, Augustine M. K. .

NATURE IMMUNOLOGY, 2011, 12 (03) :222-U57

[6] Loss of the autophagy protein Atg16L1 enhances endotoxin-induced IL-1β production [J].

Saitoh, Tatsuya ;

Fujita, Naonobu ;

Jang, Myoung Ho ;

Uematsu, Satoshi ;

Yang, Bo-Gie ;

Satoh, Takashi ;

Omori, Hiroko ;

Noda, Takeshi ;

Yamamoto, Naoki ;

Komatsu, Masaaki ;

Tanaka, Keiji ;

Kawai, Taro ;

Tsujimura, Tohru ;

Takeuchi, Osamu ;

Yoshimori, Tamotsu ;

Akira, Shizuo .

NATURE, 2008, 456 (7219) :264-U68

[7] Identification and characterization of MAVS, a mitochondrial antiviral signaling protein that activates NF-κB and IRF3 [J].

Seth, RB ;

Sun, LJ ;

Ea, CK ;

Chen, ZJJ .

CELL, 2005, 122 (05) :669-682

[8] Nod1 and Nod2 direct autophagy by recruiting ATG16L1 to the plasma membrane at the site of bacterial entry [J].

Travassos, Leonardo H. ;

Carneiro, Leticia A. M. ;

Ramjeet, Mahendrasingh ;

Hussey, Seamus ;

Kim, Yun-Gi ;

Magalhaes, Joao G. ;

Yuan, Linda ;

Soares, Fraser ;

Chea, Evelyn ;

Le Bourhis, Lionel ;

Boneca, Ivo G. ;

Allaoui, Abdelmounaaim ;

Jones, Nicola L. ;

Nunez, Gabriel ;

Girardin, Stephen E. ;

Philpott, Dana J. .

NATURE IMMUNOLOGY, 2010, 11 (01) :55-U67

[9] Molecular mechanisms of necroptosis: an ordered cellular explosion [J].

Vandenabeele, Peter ;

Galluzzi, Lorenzo ;

Vanden Berghe, Tom ;

Kroemer, Guido .

NATURE REVIEWS MOLECULAR CELL BIOLOGY, 2010, 11 (10) :700-714

[10] Circulating mitochondrial DAMPs cause inflammatory responses to injury [J].

Zhang, Qin ;

Raoof, Mustafa ;

Chen, Yu ;

Sumi, Yuka ;

Sursal, Tolga ;

Junger, Wolfgang ;

Brohi, Karim ;

Itagaki, Kiyoshi ;

Hauser, Carl J. .

NATURE, 2010, 464 (7285) :104-U115

← 1 2 →