Use of recombinant factor viia for bleeding in children with Glanzmann thrombasthenia

被引:21
作者
Çaglar, K [1 ]
Çetinkaya, A [1 ]
Aytaç, S [1 ]
Gümrük, F [1 ]
Gürgey, A [1 ]
机构
[1] Hacettepe Univ, Fac Med, Dept Pediat, Pediat Hematol Unit, TR-06100 Ankara, Turkey
关键词
children; Glanzmann thrombastenia; recombinant factor VIIa;
D O I
10.1080/08880010390220135
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Glanzmann thrombasthenia is a very rare inherited platelet function disorder in which bleeding may be extremely difficult to stop. Recombinant factor VIIa is one of the alternative treatments for bleeding. The authors report here their experience with the use of factor VIIa, which may be useful for arresting bleeding in Glazmann thrombasthenia.
引用
收藏
页码:435 / 438
页数:4
相关论文
共 9 条
[1]  
Aledort LM, 2000, THROMB HAEMOSTASIS, V83, P637
[2]  
Chuansumrit A, 1999, THROMB HAEMOSTASIS, V82, P1778
[3]  
d'Oiron R, 2000, THROMB HAEMOSTASIS, V83, P644
[4]  
HOFFMAN, 2003, BLOOD, V101, P1666
[5]   Recombinant factor VIIa enhances deposition of platelets with congenital or acquired αIIBβ3 deficiency to endothelial cell matrix and collagen under conditions of flow via tissue factor-independent thrombin generation [J].
Lisman, T ;
Moschatsis, S ;
Adelmeijer, J ;
Nieuwenhuis, HK ;
De Groot, PG .
BLOOD, 2003, 101 (05) :1864-1870
[6]   The factor VII-Platelet interplay: Effectiveness of recombinant factor VIIa in the treatment of bleeding in severe thrombocytopathia [J].
Monroe, DM ;
Hoffman, M ;
Allen, GA ;
Roberts, HR .
SEMINARS IN THROMBOSIS AND HEMOSTASIS, 2000, 26 (04) :373-377
[7]  
Patel RK, 2001, BRIT J HAEMATOL, V114, P245
[8]   Recombinant factor VIIa is effective for bleeding and surgery in patients with Glanzmann thrombasthenia [J].
Poon, MC ;
Demers, C ;
Jobin, F ;
Wu, JWY .
BLOOD, 1999, 94 (11) :3951-3953
[9]  
Tengborn L, 1996, THROMB HAEMOSTASIS, V75, P981