The role of calcium in the regulation of apoptosis

被引：224

作者：

McConkey, DJ ^{[1
]}

Orrenius, S ^{[1
]}

机构：

[1] KAROLINSKA INST,INST ENVIRONM MED,DIV TOXICOL,S-10401 STOCKHOLM,SWEDEN

来源：

JOURNAL OF LEUKOCYTE BIOLOGY | 1996年 / 59卷 / 06期

关键词：

endonuclease; oxidative stress; BCL-2;

D O I：

10.1002/jlb.59.6.775

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The recognition that apoptosis is regulated by an evolutionarily conserved set of polypeptides from the nematode Caenorhabditis elegans to humans suggests that a conserved set of biochemical mechanism(s) may also be involved in the response, Work from a number of independent laboratories suggests that alterations in cytosolic Ca2+ homeostasis represent one such candidate mechanism, and molecular targets for Ca2+ are now being identified, This review will summarize what is known about the role of Ca2+ in the regulation of apoptosis and discuss how Ca2+ might interact with some of the other biochemical signals implicated in cell death.

引用

页码：775 / 783

页数：9

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