Determination of trace elements in the human substantia nigra

被引：27

作者：

Morawski, M

Meinecke, C

Reinert, T

Dörffel, AC

Riederer, P

Arendt, T

Butz, T

机构：

[1] Univ Leipzig, Paul Flechsig Inst Hirnforsch, D-04109 Leipzig, Germany

[2] Univ Leipzig, Fak Phys & Geowissensch, D-04105 Leipzig, Germany

[3] Univ Wurzburg, Abt Psychiat, Klin Neurochem, D-97080 Wurzburg, Germany

来源：

NUCLEAR INSTRUMENTS & METHODS IN PHYSICS RESEARCH SECTION B-BEAM INTERACTIONS WITH MATERIALS AND ATOMS | 2005年 / 231卷

关键词：

life sciences; brain research; Parkinson's disease; neuromelanin; iron; nuclear methods; PIXE; substantia nigra pars compacta pars reticulata;

D O I：

10.1016/j.nimb.2005.01.061

中图分类号：

TH7 [仪器、仪表];

学科分类号：

0804 ; 080401 ; 081102 ;

摘要：

The gain in brain is mainly in the stain was long time a key sentence for research in neurodegenerative disease. However, for a quantification of the element concentrations (especially iron) in brain tissue, standard staining methods are insufficient. Advanced physical methods allow a quantitative elemental analysis of brain tissue. The sophisticated ion beam analysis provides a quantitative determination of elemental concentrations with a subcellular spatial resolution using a scanning proton beam focussed down to below 1 mu m that induces characteristic X-rays in the specimen (PIXE - particle induced X-ray emission).

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收藏

页码：224 / 228

页数：5

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